Specific effects of SARS-CoV-2 infection on different subtypes of microglia and astrocytes in human brain
Objective To investigate the impact of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections on different phenotypes of microglia and astrocytes in the human brain and their role in neurological symptoms resulted from COVID-19 infection. Methods Fourteen human hippocampus-entorhin...
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| Main Author: | |
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| Format: | Article |
| Language: | Chinese |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-07-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-7-933.pdf |
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| Summary: | Objective To investigate the impact of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infections on different phenotypes of microglia and astrocytes in the human brain and their role in neurological symptoms resulted from COVID-19 infection. Methods Fourteen human hippocampus-entorhinal cortex (HP-EC) samples were selected including 7 from COVID-19 patients and 7 from control donors. Multiplex immuno-histochemistry was used to detect markers of microglia and astrocytes followed by quantitative evaluation and statistical analysis. Results COVID-19 infection significantly changed density of microglia and astrocytes in HP-EC regions. It led to a decrease in quantity of neuro-protective, neurotoxic, and water-homeostasis-regulating astrocytes, while phagocytic microglia, chemotactic microglia and lipid-transporting astrocytes showed a region-specific density changes. Conclusions COVID-19 infection disrupts immune microenvironment of central nervous system, that may potentially contribute to the pathogenesis of COVID-19-related neurological symptoms as shown by changes of functional states of microglia and astrocytes. |
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| ISSN: | 1001-6325 |