AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management
Abstract Diabetic wound healing presents serious clinical challenges due to the unique wound microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO2)‐coated AuCu bimetallic aerogel is developed that exhibits quadr...
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202502391 |
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| author | Xiaofeng Tan Nanyun Lin Sha Yang Hongyu Gong Minghui Wang Na Li Fen Liu Dajun Rao Yingying Wu Jing Tang Qinglai Yang |
| author_facet | Xiaofeng Tan Nanyun Lin Sha Yang Hongyu Gong Minghui Wang Na Li Fen Liu Dajun Rao Yingying Wu Jing Tang Qinglai Yang |
| author_sort | Xiaofeng Tan |
| collection | DOAJ |
| description | Abstract Diabetic wound healing presents serious clinical challenges due to the unique wound microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO2)‐coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme‐mimicking activity and H2O2/O2 self‐supplying to modulate the complex microenvironment of methicillin‐resistant staphylococcus aureus (MRSA)‐infected diabetic wounds. The AuCu@CuO2 aerogels demonstrate favorable photothermal properties and mimic four enzyme‐like activities: peroxidase‐like activity for producing toxic reactive oxygen species; catalase‐like activity for decomposing H2O2 to release O2 to relieve oxidative stress and hypoxia; glucose oxidase‐like activity for reducing excessive blood glucose and glutathione peroxidase‐like activity for balancing abnormal glutathione level. The CuO2 coating facilitates a continuous and adequate in situ production of H2O2 within the mildly acidic infection microenvironment, enabling excellent antibacterial activity and reduced blood glucose levels during the initial treatment of infected diabetic wounds. Furthermore, the engineered AuCu@CuO2 aerogels not only scavenge elevated ROS during the inflammatory phase but also synergistically generate oxygen to promote wound healing. Overall, the AuCu@CuO2 aerogelsmicroenvironment can be activated by the diabetic wound infection microenvironments, alleviating inflammation, reducing hypoxia, lowering blood glucose levels, and enhancing angiogenesis and collagen fiber accumulation, thereby significantly improving diabetic wound healing. |
| format | Article |
| id | doaj-art-d5ed48bc022040d49beabd0d72c912c5 |
| institution | Matheson Library |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-d5ed48bc022040d49beabd0d72c912c52025-07-17T11:30:46ZengWileyAdvanced Science2198-38442025-07-011227n/an/a10.1002/advs.202502391AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound ManagementXiaofeng Tan0Nanyun Lin1Sha Yang2Hongyu Gong3Minghui Wang4Na Li5Fen Liu6Dajun Rao7Yingying Wu8Jing Tang9Qinglai Yang10Department of Anesthesiology Hunan Provincial Maternal and Child Health Care Hospital & NHC Key Laboratory of Birth Defect Research and Prevention & MOE Key Lab of Rare Pediatric Disease Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Hepatopancreatobiliary Surgery The First Affiliated Hospital & Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Anesthesiology Hunan Provincial Maternal and Child Health Care Hospital & NHC Key Laboratory of Birth Defect Research and Prevention & MOE Key Lab of Rare Pediatric Disease Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaDepartment of Anesthesiology Hunan Provincial Maternal and Child Health Care Hospital & NHC Key Laboratory of Birth Defect Research and Prevention & MOE Key Lab of Rare Pediatric Disease Hengyang Medical School University of South China Hengyang Hunan 421001 ChinaAbstract Diabetic wound healing presents serious clinical challenges due to the unique wound microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO2)‐coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme‐mimicking activity and H2O2/O2 self‐supplying to modulate the complex microenvironment of methicillin‐resistant staphylococcus aureus (MRSA)‐infected diabetic wounds. The AuCu@CuO2 aerogels demonstrate favorable photothermal properties and mimic four enzyme‐like activities: peroxidase‐like activity for producing toxic reactive oxygen species; catalase‐like activity for decomposing H2O2 to release O2 to relieve oxidative stress and hypoxia; glucose oxidase‐like activity for reducing excessive blood glucose and glutathione peroxidase‐like activity for balancing abnormal glutathione level. The CuO2 coating facilitates a continuous and adequate in situ production of H2O2 within the mildly acidic infection microenvironment, enabling excellent antibacterial activity and reduced blood glucose levels during the initial treatment of infected diabetic wounds. Furthermore, the engineered AuCu@CuO2 aerogels not only scavenge elevated ROS during the inflammatory phase but also synergistically generate oxygen to promote wound healing. Overall, the AuCu@CuO2 aerogelsmicroenvironment can be activated by the diabetic wound infection microenvironments, alleviating inflammation, reducing hypoxia, lowering blood glucose levels, and enhancing angiogenesis and collagen fiber accumulation, thereby significantly improving diabetic wound healing.https://doi.org/10.1002/advs.202502391diabetic wound healingH2O2 and O2 self‐supplyingmetallic aerogelsMRSA infectionmultienzyme‐like activity |
| spellingShingle | Xiaofeng Tan Nanyun Lin Sha Yang Hongyu Gong Minghui Wang Na Li Fen Liu Dajun Rao Yingying Wu Jing Tang Qinglai Yang AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management Advanced Science diabetic wound healing H2O2 and O2 self‐supplying metallic aerogels MRSA infection multienzyme‐like activity |
| title | AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management |
| title_full | AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management |
| title_fullStr | AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management |
| title_full_unstemmed | AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management |
| title_short | AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management |
| title_sort | aucu cuo2 aerogels with h2o2 o2 self supplying and quadruple enzyme like activity for mrsa infected diabetic wound management |
| topic | diabetic wound healing H2O2 and O2 self‐supplying metallic aerogels MRSA infection multienzyme‐like activity |
| url | https://doi.org/10.1002/advs.202502391 |
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