Wnt-dependent mechanism of the apical constriction of roof plate cells in developing mouse spinal cord

Apical constriction of epithelial cells usually occurs in a local portion of epithelial sheet, which results in bending of epithelial tissues. However, it is uncertain whether diffusible signal molecules, like Wnt, regulate such locally restricted events. Here, we show that Wnt ligands are required...

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Bibliographic Details
Main Authors: Takuma Shinozuka, Tadashi Okubo, Noriaki Sasai, Shinji Takada
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
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Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1571770/full
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