SITA: Predicting site-specific immunogenicity for therapeutic antibodies

Antibody humanization is critical to reduce immunogenicity and enhance efficacy in the preclinical phase of the development of therapeutic antibodies originated from animal models. Computational suggestions have long been desired, but available tools focused on immunogenicity calculation of whole an...

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Hauptverfasser: Yewei Cun, Hao Ding, Tiantian Mao, Yuan Wang, Caicui Wang, Jiajun Li, Zihao Li, Mengdie Hu, Zhiwei Cao, Tianyi Qiu
Format: Artikel
Sprache:Englisch
Veröffentlicht: Elsevier 2025-06-01
Schriftenreihe:Journal of Pharmaceutical Analysis
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Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2095177925001339
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