Interactive Effects of Ambient Ozone and Meteorological Factors on Cerebral Infarction: A Five-Year Time-Series Study
<b>Objective:</b> Our objective was to investigate the short-term effects of ambient ozone (O<sub>3</sub>) meteorological factors and their interactions on hospitalizations for cerebral infarction in Zhengzhou, China. <b>Methods</b>: Daily data on air pollutants,...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/13/7/598 |
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| Summary: | <b>Objective:</b> Our objective was to investigate the short-term effects of ambient ozone (O<sub>3</sub>) meteorological factors and their interactions on hospitalizations for cerebral infarction in Zhengzhou, China. <b>Methods</b>: Daily data on air pollutants, meteorological factors, and hospitalization of cerebral infarction patients were collected from 1 January 2019 to 31 December 2023 in Zhengzhou, China. A generalized additive model was constructed to evaluate the association between ambient O<sub>3</sub> levels and hospitalization for cerebral infarction. A distributed lag non-linear model was applied to capture lagged and non-linear exposure effects. We further examined the modifying roles of temperature, humidity, wind speed, and atmospheric pressure, and conducted stratified analyses by sex, age, and season. <b>Results</b>: O<sub>3</sub> exposure was significantly associated with increased cerebral infarction risk, particularly during the warm season. A bimodal temperature-lag pattern was observed, as follows: moderate temperatures (10–20 °C) were associated with immediate effects, while cold (<10 °C) and hot (>30 °C) temperatures were linked to delayed risks. The association of O<sub>3</sub> and hospitalizations for cerebral infarction appeared stronger under high humidity, low wind speed, and low atmospheric pressure. <b>Conclusions</b>: Short-term O<sub>3</sub> exposure and adverse meteorological conditions are jointly associated with an elevated risk of cerebral infarction. Integrated air quality and weather-based warning systems are essential for targeted stroke prevention. |
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| ISSN: | 2305-6304 |