Morphological features of complicated gastroduodenal ulcers
The objective of the study was to evaluate structural changes in the margin of gastroduodenal ulcers complicated by perforation, bleeding or penetration in terms of the features of ulcer healing.Methods and materials. Histological and IHC studies were performed on 25 patients of the main group with...
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| Format: | Article |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2022-07-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/867 |
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| author | Z. H. Osmanov M. G. Rybakova Yu. A. Tikhonova D. Ju. Semenov A. Yu. Korolkov A. A. Mylnikova |
| author_facet | Z. H. Osmanov M. G. Rybakova Yu. A. Tikhonova D. Ju. Semenov A. Yu. Korolkov A. A. Mylnikova |
| author_sort | Z. H. Osmanov |
| collection | DOAJ |
| description | The objective of the study was to evaluate structural changes in the margin of gastroduodenal ulcers complicated by perforation, bleeding or penetration in terms of the features of ulcer healing.Methods and materials. Histological and IHC studies were performed on 25 patients of the main group with perforated gastroduodenal ulcers and 23 patients of the control group with chronic recurrent ulcers complicated by bleeding and penetration. Histological sections were stained with hematoxylin and eosin, and Van Gieson's picrofuchsin. Immunohistochemical reactions were performed with antibodies to Ki-67, CD68, CD138, and CD34.Results. On macroscopic evaluation, a clear even margin of the perforation was noted. Histological examination with the background of acute dyscirculatory changes clearly shows a zone of necrosis and a weakly expressed layer of granulation tissue, which in majority of the cases was practically absent. The margin of a perforated ulcer consists of a minimally presented, clearly delimited zone of tissue detritus and a practically unchanged muscle layer. Plasma cells dominated in the cell infiltrate, and the index of proliferative activity in the epithelium of the ulcer margins was about 45 %, distributed fairly evenly.Conclusions. Perforated ulcers can be considered as a special group of ulcers with the most pronounced changes of infiltration by plasmatic cells and eosinophils, edema and acute dyscirculatory changes, uniform and fairly high proliferative activity of the epithelium. Changes in the margins of the perforated ulcer allow for complete regeneration without excessive scarring with precise suturing of the perforation. |
| format | Article |
| id | doaj-art-d3e60e08133a4e4b8f50db9f11acb042 |
| institution | Matheson Library |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj-art-d3e60e08133a4e4b8f50db9f11acb0422025-08-04T13:14:03ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072022-07-01291546210.24884/1607-4181-2022-29-1-54-62581Morphological features of complicated gastroduodenal ulcersZ. H. Osmanov0M. G. Rybakova1Yu. A. Tikhonova2D. Ju. Semenov3A. Yu. Korolkov4A. A. Mylnikova5Pavlov UniversityPavlov UniversityPavlov UniversitySaint-Petersburg State Research Institute of PhthisiopulmonologyPavlov UniversityPavlov UniversityThe objective of the study was to evaluate structural changes in the margin of gastroduodenal ulcers complicated by perforation, bleeding or penetration in terms of the features of ulcer healing.Methods and materials. Histological and IHC studies were performed on 25 patients of the main group with perforated gastroduodenal ulcers and 23 patients of the control group with chronic recurrent ulcers complicated by bleeding and penetration. Histological sections were stained with hematoxylin and eosin, and Van Gieson's picrofuchsin. Immunohistochemical reactions were performed with antibodies to Ki-67, CD68, CD138, and CD34.Results. On macroscopic evaluation, a clear even margin of the perforation was noted. Histological examination with the background of acute dyscirculatory changes clearly shows a zone of necrosis and a weakly expressed layer of granulation tissue, which in majority of the cases was practically absent. The margin of a perforated ulcer consists of a minimally presented, clearly delimited zone of tissue detritus and a practically unchanged muscle layer. Plasma cells dominated in the cell infiltrate, and the index of proliferative activity in the epithelium of the ulcer margins was about 45 %, distributed fairly evenly.Conclusions. Perforated ulcers can be considered as a special group of ulcers with the most pronounced changes of infiltration by plasmatic cells and eosinophils, edema and acute dyscirculatory changes, uniform and fairly high proliferative activity of the epithelium. Changes in the margins of the perforated ulcer allow for complete regeneration without excessive scarring with precise suturing of the perforation.https://www.sci-notes.ru/jour/article/view/867perforated ulcerstomachduodenumulcer closurehistological examinationimmunohistochemical examination |
| spellingShingle | Z. H. Osmanov M. G. Rybakova Yu. A. Tikhonova D. Ju. Semenov A. Yu. Korolkov A. A. Mylnikova Morphological features of complicated gastroduodenal ulcers Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова perforated ulcer stomach duodenum ulcer closure histological examination immunohistochemical examination |
| title | Morphological features of complicated gastroduodenal ulcers |
| title_full | Morphological features of complicated gastroduodenal ulcers |
| title_fullStr | Morphological features of complicated gastroduodenal ulcers |
| title_full_unstemmed | Morphological features of complicated gastroduodenal ulcers |
| title_short | Morphological features of complicated gastroduodenal ulcers |
| title_sort | morphological features of complicated gastroduodenal ulcers |
| topic | perforated ulcer stomach duodenum ulcer closure histological examination immunohistochemical examination |
| url | https://www.sci-notes.ru/jour/article/view/867 |
| work_keys_str_mv | AT zhosmanov morphologicalfeaturesofcomplicatedgastroduodenalulcers AT mgrybakova morphologicalfeaturesofcomplicatedgastroduodenalulcers AT yuatikhonova morphologicalfeaturesofcomplicatedgastroduodenalulcers AT djusemenov morphologicalfeaturesofcomplicatedgastroduodenalulcers AT ayukorolkov morphologicalfeaturesofcomplicatedgastroduodenalulcers AT aamylnikova morphologicalfeaturesofcomplicatedgastroduodenalulcers |