Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia
Background Gut-lung crosstalk is a pathway involving interactions between the gastrointestinal, respiratory, and immune systems. The immune responses of the gut and lungs are intricately linked, and previous studies demonstrated that the gut microbiota can influence systemic immune responses in the...
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The Korean Pediatric Society
2025-07-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://e-cep.org/upload/pdf/cep-2024-01718.pdf |
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| author | Anucha Thatrimontrichai Manapat Praditaukrit Gunlawadee Maneenil Supaporn Dissaneevate Kamonnut Singkhamanan Komwit Surachat |
| author_facet | Anucha Thatrimontrichai Manapat Praditaukrit Gunlawadee Maneenil Supaporn Dissaneevate Kamonnut Singkhamanan Komwit Surachat |
| author_sort | Anucha Thatrimontrichai |
| collection | DOAJ |
| description | Background Gut-lung crosstalk is a pathway involving interactions between the gastrointestinal, respiratory, and immune systems. The immune responses of the gut and lungs are intricately linked, and previous studies demonstrated that the gut microbiota can influence systemic immune responses in the respiratory system as well as bronchopulmonary dysplasia (BPD). Purpose To analyze the composition of the gut microbiota in very low birth weight infants with versus without BPD. Methods Secondary data from a previous randomized controlled trial were analyzed. Microbiomes were analyzed using QIIME 2 software. Gut microbiota diversity and abundance were compared between groups. Results Fifty-one neonates were classified into the BPD (n=24) and non-BPD (n=27) groups, between which no differences were noted in the alpha and beta diversities of the gut microbiota. In both groups, Proteobacteria, Gammaproteobacteria, and Klebsiella were the predominant phylum, class, and genus in gut microbiota, respectively. Enterococcus, Acinetobacter, Elizabethkingia, Clostridium sensu stricto 1, Bacteroides, Streptococcus, and Serratia were more abundant, whereas Klebsiella, Faecalibacterium, Escherichia-Shigella, Enterobacter, Bifidobacterium, Veillonella, Staphylococcus, and Enterobacteriaceae were less abundant in the BPD versus non-BPD group. Faecalibacterium, Roseburia, Clostridium, Eubacterium, and Coprococcus were significantly more abundant in the non-BPD versus BPD group. Conclusion The alpha and beta diversities of the gut microbiota did not differ significantly between the BPD and non-BPD groups. However, in terms of relative abundance, the presence of common respiratory pathogens was notable in the BPD group. Conversely, the non-BPD group had a significantly higher prevalence of anaerobic taxa known for their capacity to produce butyrate, a key component of postbiotics. |
| format | Article |
| id | doaj-art-d3312a88267b4f2dba95aac0d093ec7c |
| institution | Matheson Library |
| issn | 2713-4148 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj-art-d3312a88267b4f2dba95aac0d093ec7c2025-07-08T07:23:20ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482025-07-0168750351110.3345/cep.2024.0171820125555790Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasiaAnucha Thatrimontrichai0Manapat Praditaukrit1Gunlawadee Maneenil2Supaporn Dissaneevate3Kamonnut Singkhamanan4Komwit Surachat5 Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandBackground Gut-lung crosstalk is a pathway involving interactions between the gastrointestinal, respiratory, and immune systems. The immune responses of the gut and lungs are intricately linked, and previous studies demonstrated that the gut microbiota can influence systemic immune responses in the respiratory system as well as bronchopulmonary dysplasia (BPD). Purpose To analyze the composition of the gut microbiota in very low birth weight infants with versus without BPD. Methods Secondary data from a previous randomized controlled trial were analyzed. Microbiomes were analyzed using QIIME 2 software. Gut microbiota diversity and abundance were compared between groups. Results Fifty-one neonates were classified into the BPD (n=24) and non-BPD (n=27) groups, between which no differences were noted in the alpha and beta diversities of the gut microbiota. In both groups, Proteobacteria, Gammaproteobacteria, and Klebsiella were the predominant phylum, class, and genus in gut microbiota, respectively. Enterococcus, Acinetobacter, Elizabethkingia, Clostridium sensu stricto 1, Bacteroides, Streptococcus, and Serratia were more abundant, whereas Klebsiella, Faecalibacterium, Escherichia-Shigella, Enterobacter, Bifidobacterium, Veillonella, Staphylococcus, and Enterobacteriaceae were less abundant in the BPD versus non-BPD group. Faecalibacterium, Roseburia, Clostridium, Eubacterium, and Coprococcus were significantly more abundant in the non-BPD versus BPD group. Conclusion The alpha and beta diversities of the gut microbiota did not differ significantly between the BPD and non-BPD groups. However, in terms of relative abundance, the presence of common respiratory pathogens was notable in the BPD group. Conversely, the non-BPD group had a significantly higher prevalence of anaerobic taxa known for their capacity to produce butyrate, a key component of postbiotics.http://e-cep.org/upload/pdf/cep-2024-01718.pdfbiodiversitybronchopulmonary dysplasiagastrointestinal microbiomenecrotizing enterocolitisneonatal intensive care unitnewbornpremature infantsynbiotics |
| spellingShingle | Anucha Thatrimontrichai Manapat Praditaukrit Gunlawadee Maneenil Supaporn Dissaneevate Kamonnut Singkhamanan Komwit Surachat Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia Clinical and Experimental Pediatrics biodiversity bronchopulmonary dysplasia gastrointestinal microbiome necrotizing enterocolitis neonatal intensive care unit newborn premature infant synbiotics |
| title | Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| title_full | Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| title_fullStr | Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| title_full_unstemmed | Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| title_short | Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| title_sort | characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia |
| topic | biodiversity bronchopulmonary dysplasia gastrointestinal microbiome necrotizing enterocolitis neonatal intensive care unit newborn premature infant synbiotics |
| url | http://e-cep.org/upload/pdf/cep-2024-01718.pdf |
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