Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis
Atherosclerosis is increasingly recognized as a chronic inflammatory process, involving intricate interactions among the endothelium, lipids, coagulation system, and components of both the innate and adaptive immune systems. In the context of systemic lupus erythematosus (SLE), these interactions ar...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Lupus |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/flupu.2025.1607792/full |
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| author | Philippe Bilodeau Konstantinos Tselios |
| author_facet | Philippe Bilodeau Konstantinos Tselios |
| author_sort | Philippe Bilodeau |
| collection | DOAJ |
| description | Atherosclerosis is increasingly recognized as a chronic inflammatory process, involving intricate interactions among the endothelium, lipids, coagulation system, and components of both the innate and adaptive immune systems. In the context of systemic lupus erythematosus (SLE), these interactions are even further disrupted, contributing to accelerated atherosclerosis. This narrative review explores how immune system dysregulation plays a central role in the development of atherosclerosis in SLE patients, where cardiovascular disease remains the leading cause of mortality despite recent advancements. We aim to present a model based on current scientific evidence that compares the immune mechanisms driving atherosclerosis in the general population with the accelerated form observed in SLE patients, highlighting the key immunological distinctions that set SLE-associated atherosclerosis apart. Particular emphasis was given to the interactions between interferon, lipid alterations and adaptive immunity as mediators of atherogenesis. This model may help identify gaps in our understanding and generate new hypotheses for potential therapeutic targets to modulate immune responses within atherosclerotic plaques. |
| format | Article |
| id | doaj-art-d29f83eccfbe4eb9b0b521a89f0362d7 |
| institution | Matheson Library |
| issn | 2813-6934 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Lupus |
| spelling | doaj-art-d29f83eccfbe4eb9b0b521a89f0362d72025-06-25T05:25:12ZengFrontiers Media S.A.Frontiers in Lupus2813-69342025-06-01310.3389/flupu.2025.16077921607792Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesisPhilippe BilodeauKonstantinos TseliosAtherosclerosis is increasingly recognized as a chronic inflammatory process, involving intricate interactions among the endothelium, lipids, coagulation system, and components of both the innate and adaptive immune systems. In the context of systemic lupus erythematosus (SLE), these interactions are even further disrupted, contributing to accelerated atherosclerosis. This narrative review explores how immune system dysregulation plays a central role in the development of atherosclerosis in SLE patients, where cardiovascular disease remains the leading cause of mortality despite recent advancements. We aim to present a model based on current scientific evidence that compares the immune mechanisms driving atherosclerosis in the general population with the accelerated form observed in SLE patients, highlighting the key immunological distinctions that set SLE-associated atherosclerosis apart. Particular emphasis was given to the interactions between interferon, lipid alterations and adaptive immunity as mediators of atherogenesis. This model may help identify gaps in our understanding and generate new hypotheses for potential therapeutic targets to modulate immune responses within atherosclerotic plaques.https://www.frontiersin.org/articles/10.3389/flupu.2025.1607792/fullsystemic lupus erythematosus (SLE)neutrophil extracellular trap (NET)dyslipidemia (DLP)type I interferon (IFN-I)b cell subsetmitochondrial dysfunction |
| spellingShingle | Philippe Bilodeau Konstantinos Tselios Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis Frontiers in Lupus systemic lupus erythematosus (SLE) neutrophil extracellular trap (NET) dyslipidemia (DLP) type I interferon (IFN-I) b cell subset mitochondrial dysfunction |
| title | Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis |
| title_full | Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis |
| title_fullStr | Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis |
| title_full_unstemmed | Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis |
| title_short | Immune dysregulation and lipid interactions in systemic lupus erythematosus-associated atherosclerosis: mechanisms and pathogenesis |
| title_sort | immune dysregulation and lipid interactions in systemic lupus erythematosus associated atherosclerosis mechanisms and pathogenesis |
| topic | systemic lupus erythematosus (SLE) neutrophil extracellular trap (NET) dyslipidemia (DLP) type I interferon (IFN-I) b cell subset mitochondrial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/flupu.2025.1607792/full |
| work_keys_str_mv | AT philippebilodeau immunedysregulationandlipidinteractionsinsystemiclupuserythematosusassociatedatherosclerosismechanismsandpathogenesis AT konstantinostselios immunedysregulationandlipidinteractionsinsystemiclupuserythematosusassociatedatherosclerosismechanismsandpathogenesis |