Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity.
Brain oscillations and synchronicity among brain regions (brain connectivity) have been studied in resting-state (RS) and task-induced settings. RS-connectivity which captures brain functional integration during an unconstrained state is shown to vary with the frequency of oscillations. Indeed, high...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0171647 |
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| author | Maziar Yaesoubi Robyn L Miller Vince D Calhoun |
| author_facet | Maziar Yaesoubi Robyn L Miller Vince D Calhoun |
| author_sort | Maziar Yaesoubi |
| collection | DOAJ |
| description | Brain oscillations and synchronicity among brain regions (brain connectivity) have been studied in resting-state (RS) and task-induced settings. RS-connectivity which captures brain functional integration during an unconstrained state is shown to vary with the frequency of oscillations. Indeed, high temporal resolution modalities have demonstrated both between and cross-frequency connectivity spanning across frequency bands such as theta and gamma. Despite high spatial resolution, functional magnetic resonance imaging (fMRI) suffers from low temporal resolution due to modulation with slow-varying hemodynamic response function (HRF) and also relatively low sampling rate. This limits the range of detectable frequency bands in fMRI and consequently there has been no evidence of cross-frequency dependence in fMRI data. In the present work we uncover recurring patterns of spectral power in network timecourses which provides new insight on the actual nature of frequency variation in fMRI network activations. Moreover, we introduce a new measure of dependence between pairs of rs-fMRI networks which reveals significant cross-frequency dependence between functional brain networks specifically default-mode, cerebellar and visual networks. This is the first strong evidence of cross-frequency dependence between functional networks in fMRI and our subject group analysis based on age and gender supports usefulness of this observation for future clinical applications. |
| format | Article |
| id | doaj-art-d25e636bfaf74f298889674bc3a7916e |
| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d25e636bfaf74f298889674bc3a7916e2025-06-25T05:32:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017164710.1371/journal.pone.0171647Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity.Maziar YaesoubiRobyn L MillerVince D CalhounBrain oscillations and synchronicity among brain regions (brain connectivity) have been studied in resting-state (RS) and task-induced settings. RS-connectivity which captures brain functional integration during an unconstrained state is shown to vary with the frequency of oscillations. Indeed, high temporal resolution modalities have demonstrated both between and cross-frequency connectivity spanning across frequency bands such as theta and gamma. Despite high spatial resolution, functional magnetic resonance imaging (fMRI) suffers from low temporal resolution due to modulation with slow-varying hemodynamic response function (HRF) and also relatively low sampling rate. This limits the range of detectable frequency bands in fMRI and consequently there has been no evidence of cross-frequency dependence in fMRI data. In the present work we uncover recurring patterns of spectral power in network timecourses which provides new insight on the actual nature of frequency variation in fMRI network activations. Moreover, we introduce a new measure of dependence between pairs of rs-fMRI networks which reveals significant cross-frequency dependence between functional brain networks specifically default-mode, cerebellar and visual networks. This is the first strong evidence of cross-frequency dependence between functional networks in fMRI and our subject group analysis based on age and gender supports usefulness of this observation for future clinical applications.https://doi.org/10.1371/journal.pone.0171647 |
| spellingShingle | Maziar Yaesoubi Robyn L Miller Vince D Calhoun Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. PLoS ONE |
| title | Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. |
| title_full | Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. |
| title_fullStr | Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. |
| title_full_unstemmed | Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. |
| title_short | Time-varying spectral power of resting-state fMRI networks reveal cross-frequency dependence in dynamic connectivity. |
| title_sort | time varying spectral power of resting state fmri networks reveal cross frequency dependence in dynamic connectivity |
| url | https://doi.org/10.1371/journal.pone.0171647 |
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