Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids
Objective. To compare bone mineral density (BMD) in pts with systemic lupus erythematosus (SLE), treated and untreated by glucocorticoids (GC). Matherial and Methods. 30 females with reliable SLE were examined (APA, 1982), 15 had GC (prednisolone 7.5-60mg/day, median cumulative dose 10.7±6.6g) (1st...
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IMA PRESS LLC
2004-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1230 |
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| author | L A Archakova N M Kosheleva A V Smirnov Z S Alekberova |
| author_facet | L A Archakova N M Kosheleva A V Smirnov Z S Alekberova |
| author_sort | L A Archakova |
| collection | DOAJ |
| description | Objective. To compare bone mineral density (BMD) in pts with systemic lupus erythematosus (SLE), treated and untreated by glucocorticoids (GC). Matherial and Methods. 30 females with reliable SLE were examined (APA, 1982), 15 had GC (prednisolone 7.5-60mg/day, median cumulative dose 10.7±6.6g) (1st group), 15 others did not take GC (2nd group). Groups were comparable by age, SLE course duration, body weight. All were females with normal menses period. BMD was assessed in low back vertebral region and femoral neck in standard projections on dichromatic X-ray densitometer QDR-1000 Plus (Hologic, USA) in absolute values (g/cm2) and T-index. Results. BMD in low back was statistically reliably lower in the 1st group as compared with the 2nd (0,918±0,118 and 1,036±0,156; p=0,027). In the left femoral neck there were no differences in mineralization of bone tissue (0,769±0,167 and 0,807±0,227; p=0,568), BMD decreasing in the studied bone region reliably prevailed among pts of the 1st group (n=ll) as compared with the 2nd (n=2) (p=0.003). Conclusion. SLE pis treated by GC demonstrated reliably lower indices of BMD in LI-L4 as compared with pts who were not treated by GC. |
| format | Article |
| id | doaj-art-d17d6b56fc1a4a32aa135a1ca3d7671f |
| institution | Matheson Library |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2004-02-01 |
| publisher | IMA PRESS LLC |
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| series | Научно-практическая ревматология |
| spelling | doaj-art-d17d6b56fc1a4a32aa135a1ca3d7671f2025-08-04T17:03:46ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922004-02-01421192310.14412/1995-4484-2004-13771170Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoidsL A ArchakovaN M KoshelevaA V SmirnovZ S AlekberovaObjective. To compare bone mineral density (BMD) in pts with systemic lupus erythematosus (SLE), treated and untreated by glucocorticoids (GC). Matherial and Methods. 30 females with reliable SLE were examined (APA, 1982), 15 had GC (prednisolone 7.5-60mg/day, median cumulative dose 10.7±6.6g) (1st group), 15 others did not take GC (2nd group). Groups were comparable by age, SLE course duration, body weight. All were females with normal menses period. BMD was assessed in low back vertebral region and femoral neck in standard projections on dichromatic X-ray densitometer QDR-1000 Plus (Hologic, USA) in absolute values (g/cm2) and T-index. Results. BMD in low back was statistically reliably lower in the 1st group as compared with the 2nd (0,918±0,118 and 1,036±0,156; p=0,027). In the left femoral neck there were no differences in mineralization of bone tissue (0,769±0,167 and 0,807±0,227; p=0,568), BMD decreasing in the studied bone region reliably prevailed among pts of the 1st group (n=ll) as compared with the 2nd (n=2) (p=0.003). Conclusion. SLE pis treated by GC demonstrated reliably lower indices of BMD in LI-L4 as compared with pts who were not treated by GC.https://rsp.mediar-press.net/rsp/article/view/1230systemic lupus erythematosusmineral bone densityglucocorticoids |
| spellingShingle | L A Archakova N M Kosheleva A V Smirnov Z S Alekberova Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids Научно-практическая ревматология systemic lupus erythematosus mineral bone density glucocorticoids |
| title | Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| title_full | Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| title_fullStr | Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| title_full_unstemmed | Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| title_short | Mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| title_sort | mineral bone density comparative assessment in patients with systemic lupus erythematosus treated and not treated with glucocorticoids |
| topic | systemic lupus erythematosus mineral bone density glucocorticoids |
| url | https://rsp.mediar-press.net/rsp/article/view/1230 |
| work_keys_str_mv | AT laarchakova mineralbonedensitycomparativeassessmentinpatientswithsystemiclupuserythematosustreatedandnottreatedwithglucocorticoids AT nmkosheleva mineralbonedensitycomparativeassessmentinpatientswithsystemiclupuserythematosustreatedandnottreatedwithglucocorticoids AT avsmirnov mineralbonedensitycomparativeassessmentinpatientswithsystemiclupuserythematosustreatedandnottreatedwithglucocorticoids AT zsalekberova mineralbonedensitycomparativeassessmentinpatientswithsystemiclupuserythematosustreatedandnottreatedwithglucocorticoids |