Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey
Background: The association between uterine fibroids and mortality remains inconclusive. This study evaluated the relationship between uterine fibroids and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality using data from the National Health and Nutri...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG38505 |
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| author | Lijie Liu Chuan Shao Lujia Li Nan Wu |
| author_facet | Lijie Liu Chuan Shao Lujia Li Nan Wu |
| author_sort | Lijie Liu |
| collection | DOAJ |
| description | Background: The association between uterine fibroids and mortality remains inconclusive. This study evaluated the relationship between uterine fibroids and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Methods: A cohort analysis was conducted using NHANES data from 1999 to 2006. Weighted Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations between uterine fibroids, age at diagnosis, and mortality outcomes. Subgroup analyses and interaction tests were performed to evaluate potential effect modification. Results: The study cohort comprised 5547 women aged 20–54 years across four survey cycles. During a median follow-up of 16.75 years, 290 deaths were recorded. After adjustment for confounders, no statistically significant associations were observed for all-cause mortality (HR: 0.96; 95% CI: 0.65–1.42), cancer-specific mortality (HR: 1.12; 95% CI: 0.64–1.96), or CVD-related mortality (HR: 0.90; 95% CI: 0.38–2.14). Age-stratified analyses similarly revealed no significant associations across diagnostic age groups. Conclusions: These results indicate no elevated risk of all-cause, cancer-specific, or CVD-specific mortality associated with uterine fibroids. |
| format | Article |
| id | doaj-art-d0d6e8c4dc2f45e9a1a9dc160b959fa5 |
| institution | Matheson Library |
| issn | 0390-6663 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-d0d6e8c4dc2f45e9a1a9dc160b959fa52025-07-08T07:03:51ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632025-06-015263850510.31083/CEOG38505S0390-6663(25)02616-8Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination SurveyLijie Liu0Chuan Shao1Lujia Li2Nan Wu3Department of Health Care, People’s Liberation Army Navy 971 Hospital, 266071 Qingdao, Shandong, ChinaDepartment of Neurosurgery, Chongqing General Hospital, Chongqing University, 401147 Chongqing, ChinaDepartment of Health Care, People’s Liberation Army Navy 971 Hospital, 266071 Qingdao, Shandong, ChinaDepartment of Neurosurgery, Chongqing General Hospital, Chongqing University, 401147 Chongqing, ChinaBackground: The association between uterine fibroids and mortality remains inconclusive. This study evaluated the relationship between uterine fibroids and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Methods: A cohort analysis was conducted using NHANES data from 1999 to 2006. Weighted Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations between uterine fibroids, age at diagnosis, and mortality outcomes. Subgroup analyses and interaction tests were performed to evaluate potential effect modification. Results: The study cohort comprised 5547 women aged 20–54 years across four survey cycles. During a median follow-up of 16.75 years, 290 deaths were recorded. After adjustment for confounders, no statistically significant associations were observed for all-cause mortality (HR: 0.96; 95% CI: 0.65–1.42), cancer-specific mortality (HR: 1.12; 95% CI: 0.64–1.96), or CVD-related mortality (HR: 0.90; 95% CI: 0.38–2.14). Age-stratified analyses similarly revealed no significant associations across diagnostic age groups. Conclusions: These results indicate no elevated risk of all-cause, cancer-specific, or CVD-specific mortality associated with uterine fibroids.https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG38505uterine fibroidsmortalitycohortnhanesrisk |
| spellingShingle | Lijie Liu Chuan Shao Lujia Li Nan Wu Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey Clinical and Experimental Obstetrics & Gynecology uterine fibroids mortality cohort nhanes risk |
| title | Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey |
| title_full | Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey |
| title_fullStr | Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey |
| title_full_unstemmed | Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey |
| title_short | Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey |
| title_sort | uterine fibroids and all cause and cause specific mortality analysis from the national health and nutrition examination survey |
| topic | uterine fibroids mortality cohort nhanes risk |
| url | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG38505 |
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