Uterine Fibroids and All-Cause and Cause-Specific Mortality: Analysis From the National Health and Nutrition Examination Survey
Background: The association between uterine fibroids and mortality remains inconclusive. This study evaluated the relationship between uterine fibroids and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality using data from the National Health and Nutri...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG38505 |
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| Summary: | Background: The association between uterine fibroids and mortality remains inconclusive. This study evaluated the relationship between uterine fibroids and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006. Methods: A cohort analysis was conducted using NHANES data from 1999 to 2006. Weighted Cox proportional hazards regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) to assess associations between uterine fibroids, age at diagnosis, and mortality outcomes. Subgroup analyses and interaction tests were performed to evaluate potential effect modification. Results: The study cohort comprised 5547 women aged 20–54 years across four survey cycles. During a median follow-up of 16.75 years, 290 deaths were recorded. After adjustment for confounders, no statistically significant associations were observed for all-cause mortality (HR: 0.96; 95% CI: 0.65–1.42), cancer-specific mortality (HR: 1.12; 95% CI: 0.64–1.96), or CVD-related mortality (HR: 0.90; 95% CI: 0.38–2.14). Age-stratified analyses similarly revealed no significant associations across diagnostic age groups. Conclusions: These results indicate no elevated risk of all-cause, cancer-specific, or CVD-specific mortality associated with uterine fibroids. |
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| ISSN: | 0390-6663 |