The cost-effectiveness of different diagnostic options of TB among HIV-infected patients
Diagnostic of active tuberculosis among HIV – infected people is difficult problem, demanding of significant healthcare costs.The objective: to evaluate the cost-effectiveness of different diagnostic scenarios detecting tuberculosis among HIVinfected.Material and methods: the evaluation was carried...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2014-12-01
|
| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839572094988320768 |
|---|---|
| author | V. E. Shumlyanskaya A. V. Rudakova |
| author_facet | V. E. Shumlyanskaya A. V. Rudakova |
| author_sort | V. E. Shumlyanskaya |
| collection | DOAJ |
| description | Diagnostic of active tuberculosis among HIV – infected people is difficult problem, demanding of significant healthcare costs.The objective: to evaluate the cost-effectiveness of different diagnostic scenarios detecting tuberculosis among HIVinfected.Material and methods: the evaluation was carried out through modeling, from the health care system perspective, in cohorts with different CD 4+ counts (<200, 200–499, >500). The three scenarios were examined: (1) «Base» – the current TB diagnostic scheme in the Russia; (2) «Addition» – the «Base» scenario augmented by Xpert/Rif; (3) «Replacement » – only one Gene Xpert/Rif.Results: using «Addition» scenario in CD 4+cohort <200, allows to detect 8 additional TB patients per 1000 HIV-infected people, significantly increases the number of effectively treated patients, including patients with initial rifampicin drug resistant, prevents 5 deaths, reduce opportunity oftransmission TB and further spread TB in population. Additional costs per one additional effectively treated patient, identified in the «Addition» scenario, compared to «Basic», is 1130 thousand rubles, additional costs per one prevented death is 943 thousand rubles. Using the algorithm «Replacement » can lead to significant diagnostic delays, its use hasneither clinical nor economic feasibility.Conclusions: adding Gene Xpert MBT/Rif to the TB diagnosticalgorithm is economically feasible in patient cohort with CD 4+ <200 cells/ml. |
| format | Article |
| id | doaj-art-d0cb0e3948e541bdb0f3de5c93ba68e2 |
| institution | Matheson Library |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-12-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-d0cb0e3948e541bdb0f3de5c93ba68e22025-08-04T14:25:42ZrusJournal InfectologyЖурнал инфектологии2072-67322014-12-0164738110.22625/2072-6732-2014-6-4-73-81375The cost-effectiveness of different diagnostic options of TB among HIV-infected patientsV. E. Shumlyanskaya0A. V. Rudakova1Saint-Petersburg State Chemical Pharmaceutical Academy, Saint-Petersburg, RussiaSaint-Petersburg State Chemical Pharmaceutical Academy, Saint-Petersburg, Russia Science Research Institute of Children’s Infections, Saint-Petersburg, RussiaDiagnostic of active tuberculosis among HIV – infected people is difficult problem, demanding of significant healthcare costs.The objective: to evaluate the cost-effectiveness of different diagnostic scenarios detecting tuberculosis among HIVinfected.Material and methods: the evaluation was carried out through modeling, from the health care system perspective, in cohorts with different CD 4+ counts (<200, 200–499, >500). The three scenarios were examined: (1) «Base» – the current TB diagnostic scheme in the Russia; (2) «Addition» – the «Base» scenario augmented by Xpert/Rif; (3) «Replacement » – only one Gene Xpert/Rif.Results: using «Addition» scenario in CD 4+cohort <200, allows to detect 8 additional TB patients per 1000 HIV-infected people, significantly increases the number of effectively treated patients, including patients with initial rifampicin drug resistant, prevents 5 deaths, reduce opportunity oftransmission TB and further spread TB in population. Additional costs per one additional effectively treated patient, identified in the «Addition» scenario, compared to «Basic», is 1130 thousand rubles, additional costs per one prevented death is 943 thousand rubles. Using the algorithm «Replacement » can lead to significant diagnostic delays, its use hasneither clinical nor economic feasibility.Conclusions: adding Gene Xpert MBT/Rif to the TB diagnosticalgorithm is economically feasible in patient cohort with CD 4+ <200 cells/ml.https://journal.niidi.ru/jofin/article/view/361tuberculosishivcost-effectivenessdiagnostics. |
| spellingShingle | V. E. Shumlyanskaya A. V. Rudakova The cost-effectiveness of different diagnostic options of TB among HIV-infected patients Журнал инфектологии tuberculosis hiv cost-effectiveness diagnostics. |
| title | The cost-effectiveness of different diagnostic options of TB among HIV-infected patients |
| title_full | The cost-effectiveness of different diagnostic options of TB among HIV-infected patients |
| title_fullStr | The cost-effectiveness of different diagnostic options of TB among HIV-infected patients |
| title_full_unstemmed | The cost-effectiveness of different diagnostic options of TB among HIV-infected patients |
| title_short | The cost-effectiveness of different diagnostic options of TB among HIV-infected patients |
| title_sort | cost effectiveness of different diagnostic options of tb among hiv infected patients |
| topic | tuberculosis hiv cost-effectiveness diagnostics. |
| url | https://journal.niidi.ru/jofin/article/view/361 |
| work_keys_str_mv | AT veshumlyanskaya thecosteffectivenessofdifferentdiagnosticoptionsoftbamonghivinfectedpatients AT avrudakova thecosteffectivenessofdifferentdiagnosticoptionsoftbamonghivinfectedpatients AT veshumlyanskaya costeffectivenessofdifferentdiagnosticoptionsoftbamonghivinfectedpatients AT avrudakova costeffectivenessofdifferentdiagnosticoptionsoftbamonghivinfectedpatients |