Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive)
The article presents the results of a clinical investigation on the administration of the Grippol Quadrivalent vaccine (influenza tetravalent inactivated subunit adjuvant vaccine) in children from 6 months to 5 years old. The vaccine has demonstrated no less effectiveness in comparison with the Grip...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2024-07-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/2433 |
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| author | Viktor V. Romanenko Leyla S. Namazova-Baranova Alina A. Kotova Kamilla E. Efendieva Anna A. Ruleva Ekaterina A. Khait Olga A. Perminova Tatiana E. Pak Svetlana G. Lazareva Liubov V. Aleshina Dmitriy A. Suprun Anna N. Galustyan Olga A. Rychkova Tatiana A. Romanova Alfia I. Aminova Galina V. Dulova |
| author_facet | Viktor V. Romanenko Leyla S. Namazova-Baranova Alina A. Kotova Kamilla E. Efendieva Anna A. Ruleva Ekaterina A. Khait Olga A. Perminova Tatiana E. Pak Svetlana G. Lazareva Liubov V. Aleshina Dmitriy A. Suprun Anna N. Galustyan Olga A. Rychkova Tatiana A. Romanova Alfia I. Aminova Galina V. Dulova |
| author_sort | Viktor V. Romanenko |
| collection | DOAJ |
| description | The article presents the results of a clinical investigation on the administration of the Grippol Quadrivalent vaccine (influenza tetravalent inactivated subunit adjuvant vaccine) in children from 6 months to 5 years old. The vaccine has demonstrated no less effectiveness in comparison with the Grippol plus vaccine (influenza trivalent inactivated polymer-subunit vaccine).comparable results were obtained for all evaluated indicators of immunological efficacy against matching strains of the influenza virus, while for additional strain B (Yamagata line) there was a statistically significant difference in the increase in the immune response in the Grippol Quadrivalent group. The results of the assessment of the reactogenicity and frequency of systemic adverse events indicated a favorable and comparable safety profile of the vaccines Grippol Quadrivalent and Grippol plus in children from 6 months to 5 years old. The data obtained allowed us to conclude that the immunological efficacy of the Grippol Quadrivalent vaccine is no less when compared to the Grippol plus vaccine, as well as a comparable safety and reactogenicity profile. According to the results of the clinical investigation, on 08/04/2023, the Ministry of Health of the Russian Federation amended the “Instructions for the medical use of the drug”: Grippol Quadrivalent is indicated for children from the age of 6 months. |
| format | Article |
| id | doaj-art-d05dd0dc0ddc439b9eceb09f74d85f00 |
| institution | Matheson Library |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2024-07-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-d05dd0dc0ddc439b9eceb09f74d85f002025-08-03T19:21:31ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892024-07-0121321322510.15690/pf.v21i3.27432068Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive)Viktor V. Romanenko0Leyla S. Namazova-Baranova1Alina A. Kotova2Kamilla E. Efendieva3Anna A. Ruleva4Ekaterina A. Khait5Olga A. Perminova6Tatiana E. Pak7Svetlana G. Lazareva8Liubov V. Aleshina9Dmitriy A. Suprun10Anna N. Galustyan11Olga A. Rychkova12Tatiana A. Romanova13Alfia I. Aminova14Galina V. Dulova15Ural State Medical UniversityResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryThe Center for Hygiene and Epidemiology in the SverdlovskResearch Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of SurgeryChildren’s Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological AgencyChildren’s city outpatients clinic № 45 of the Nevsky districtChildren’s city outpatients clinic № 5LLC “PiterKlinika”LLC “Energiia zdorovia”LLC “Tsentr DNK-issledovanii”Municipal Polyclinic № 106, Children’s polyclinic department № 37LLC “Meditsinskie tekhnologii”Tyumen State Medical UniversityN.N. Ivanova Samara Regional Children’s Clinical HospitalG.N. Speransky Children’s City Clinical Hospital № 9LLC “Klinika UZI 4D”The article presents the results of a clinical investigation on the administration of the Grippol Quadrivalent vaccine (influenza tetravalent inactivated subunit adjuvant vaccine) in children from 6 months to 5 years old. The vaccine has demonstrated no less effectiveness in comparison with the Grippol plus vaccine (influenza trivalent inactivated polymer-subunit vaccine).comparable results were obtained for all evaluated indicators of immunological efficacy against matching strains of the influenza virus, while for additional strain B (Yamagata line) there was a statistically significant difference in the increase in the immune response in the Grippol Quadrivalent group. The results of the assessment of the reactogenicity and frequency of systemic adverse events indicated a favorable and comparable safety profile of the vaccines Grippol Quadrivalent and Grippol plus in children from 6 months to 5 years old. The data obtained allowed us to conclude that the immunological efficacy of the Grippol Quadrivalent vaccine is no less when compared to the Grippol plus vaccine, as well as a comparable safety and reactogenicity profile. According to the results of the clinical investigation, on 08/04/2023, the Ministry of Health of the Russian Federation amended the “Instructions for the medical use of the drug”: Grippol Quadrivalent is indicated for children from the age of 6 months.https://www.pedpharma.ru/jour/article/view/2433influenza virus infectionvaccinizationinfluenza tetravalent inactivated subunit adjuvant vaccinegrippol quadrivalent |
| spellingShingle | Viktor V. Romanenko Leyla S. Namazova-Baranova Alina A. Kotova Kamilla E. Efendieva Anna A. Ruleva Ekaterina A. Khait Olga A. Perminova Tatiana E. Pak Svetlana G. Lazareva Liubov V. Aleshina Dmitriy A. Suprun Anna N. Galustyan Olga A. Rychkova Tatiana A. Romanova Alfia I. Aminova Galina V. Dulova Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) Педиатрическая фармакология influenza virus infection vaccinization influenza tetravalent inactivated subunit adjuvant vaccine grippol quadrivalent |
| title | Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) |
| title_full | Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) |
| title_fullStr | Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) |
| title_full_unstemmed | Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) |
| title_short | Results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine Grippol Quadrivalent in children aged 6 months to 5 years (inclusive) |
| title_sort | results of a clinical study of the influenza tetravalent inactivated subunit adjuvant vaccine grippol quadrivalent in children aged 6 months to 5 years inclusive |
| topic | influenza virus infection vaccinization influenza tetravalent inactivated subunit adjuvant vaccine grippol quadrivalent |
| url | https://www.pedpharma.ru/jour/article/view/2433 |
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