Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure

Sleep and Risk of Multiple Sclerosis: Bridging the Gap Between Inflammation and Neurodegeneration via Glymphatic Failure

Epidemiological studies identified insufficient and poor-quality sleep as independent risk factors for multiple sclerosis (MS). The glymphatic system, active during slow-wave sleep, clears brain waste through perivascular astrocytic aquaporin-4 (AQP4) channels. The presence of antigens induces a tra...

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Bibliographic Details
Main Authors: Mariateresa Buongiorno, Carmen Tur, Darly Milena Giraldo, Natalia Cullell, Jerzy Krupinski, Roberta Lanzillo, Gonzalo Sánchez-Benavides
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Brain Sciences
Subjects:
multiple sclerosis
glymphatic system
sleep
inflammation
neurodegeneration
Online Access:https://www.mdpi.com/2076-3425/15/7/766
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