PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population
PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RN...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-07-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317706914 |
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| author | Jiatong Li Dongwei Dou Ping Li Wenqi Luo Wenxin Lv Chengdong Zhang Xiaowei Song Yuan Yang Yuening Zhang Yanzhen Xu Feifan Xiao Yan Wei Jian Qin Hongtao Li Xiaoli Yang |
| author_facet | Jiatong Li Dongwei Dou Ping Li Wenqi Luo Wenxin Lv Chengdong Zhang Xiaowei Song Yuan Yang Yuening Zhang Yanzhen Xu Feifan Xiao Yan Wei Jian Qin Hongtao Li Xiaoli Yang |
| author_sort | Jiatong Li |
| collection | DOAJ |
| description | PARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RNA expression in patients with hepatocellular carcinoma using The Cancer Genome Atlas dataset. Increased PARP-1 expression, related to alpha-fetoprotein level, was observed. The area under the receiver operating characteristic curve value was 0.833. Kaplan–Meier survival curves indicated that higher PARP-1 expression was not correlated with poorer overall survival and recurrence-free survival. In a Zhuang population, PARP-1 messenger RNA and protein levels were increased in the hepatocellular carcinoma tissue and its adjacent liver tissues as assessed by quantitative polymerase chain reaction, immunohistochemistry, and western blotting. Higher PARP-1 level was associated with a higher tumor stage (p < 0.05), without correlation with age, gender, smoking, drinking, tumor size, serum alpha-fetoprotein level, hepatitis B virus infection, metastasis, and invasion (p > 0.05). Further analysis suggested that H2AX , a PARP-1 protein interaction partner, was coordinated with PARP-1 in hepatocellular carcinoma tumorigenesis. Overall, some new characteristics of PARP-1 expression were noted in the Zhuang population. PARP-1 is a novel promising diagnostic marker for hepatocellular carcinoma in the Southern Chinese Zhuang population. |
| format | Article |
| id | doaj-art-d021c0fd5b924f7ea85fd0e270d20a68 |
| institution | Matheson Library |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-d021c0fd5b924f7ea85fd0e270d20a682025-08-02T19:56:55ZengSAGE PublishingTumor Biology1423-03802017-07-013910.1177/1010428317706914PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang populationJiatong Li0Dongwei Dou1Ping Li2Wenqi Luo3Wenxin Lv4Chengdong Zhang5Xiaowei Song6Yuan Yang7Yuening Zhang8Yanzhen Xu9Feifan Xiao10Yan Wei11Jian Qin12Hongtao Li13Xiaoli Yang14Medical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. ChinaDepartment of Urology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, P.R. ChinaSchool of Life Sciences, Fudan University, Shanghai, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaSchool of Life Sciences, Fudan University, Shanghai, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaDepartment of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. ChinaSchool of Public Health, Guangxi Medical University, Nanning, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaMedical Scientific Research Center, Guangxi Medical University, Nanning, P.R. ChinaPARP-1 (poly(ADP-ribose) polymerase-1) plays an important role in tumorigenesis. Since its effects on different populations are varied, this study investigated the impact of PARP-1 on primary hepatocellular carcinoma in a Southern Chinese Zhuang population. We assessed the global PARP-1 messenger RNA expression in patients with hepatocellular carcinoma using The Cancer Genome Atlas dataset. Increased PARP-1 expression, related to alpha-fetoprotein level, was observed. The area under the receiver operating characteristic curve value was 0.833. Kaplan–Meier survival curves indicated that higher PARP-1 expression was not correlated with poorer overall survival and recurrence-free survival. In a Zhuang population, PARP-1 messenger RNA and protein levels were increased in the hepatocellular carcinoma tissue and its adjacent liver tissues as assessed by quantitative polymerase chain reaction, immunohistochemistry, and western blotting. Higher PARP-1 level was associated with a higher tumor stage (p < 0.05), without correlation with age, gender, smoking, drinking, tumor size, serum alpha-fetoprotein level, hepatitis B virus infection, metastasis, and invasion (p > 0.05). Further analysis suggested that H2AX , a PARP-1 protein interaction partner, was coordinated with PARP-1 in hepatocellular carcinoma tumorigenesis. Overall, some new characteristics of PARP-1 expression were noted in the Zhuang population. PARP-1 is a novel promising diagnostic marker for hepatocellular carcinoma in the Southern Chinese Zhuang population.https://doi.org/10.1177/1010428317706914 |
| spellingShingle | Jiatong Li Dongwei Dou Ping Li Wenqi Luo Wenxin Lv Chengdong Zhang Xiaowei Song Yuan Yang Yuening Zhang Yanzhen Xu Feifan Xiao Yan Wei Jian Qin Hongtao Li Xiaoli Yang PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population Tumor Biology |
| title | PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population |
| title_full | PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population |
| title_fullStr | PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population |
| title_full_unstemmed | PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population |
| title_short | PARP-1 serves as a novel molecular marker for hepatocellular carcinoma in a Southern Chinese Zhuang population |
| title_sort | parp 1 serves as a novel molecular marker for hepatocellular carcinoma in a southern chinese zhuang population |
| url | https://doi.org/10.1177/1010428317706914 |
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