Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation
Objective To research whether radiation-induced liver damage and fibrosis could be mitigated by resveratrol (RSV) and to elucidate its underlying mechanism. Methods A radiation-induced liver damage (RILD) model of murine was constructed. RSV was used as an intervention agent. The effects of RSV on i...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/17534259251352623 |
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| author | Songhui Zhai He Xu Jianxin Xue Lu Gan Fang Gao Lijuan Hu |
| author_facet | Songhui Zhai He Xu Jianxin Xue Lu Gan Fang Gao Lijuan Hu |
| author_sort | Songhui Zhai |
| collection | DOAJ |
| description | Objective To research whether radiation-induced liver damage and fibrosis could be mitigated by resveratrol (RSV) and to elucidate its underlying mechanism. Methods A radiation-induced liver damage (RILD) model of murine was constructed. RSV was used as an intervention agent. The effects of RSV on inflammatory reaction, apoptosis, senescence, fibrosis, survival, and liver functions were detected by β-Gal, Sirius red, Masson's trichrome, and Tunnel staining using an automated biochemistry analyzer. The protein expression levels of P16 and P21 were detected by Western blot. Results RSV alleviated inflammatory injury of RILD mice. RSV decreased the serum pro-inflammatory cytokines of RILD mice. RSV alleviated radiation-induced hepatocellular senescence. The protein expression levels of P16 and P21 in RILD mice were decreased with RSV administration. RSV decreased the number of apoptotic cells in the early stage of RILD. RSV alleviated liver fibrosis and liver function in RILD mice. Conclusions RSV reduces RILD and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation. |
| format | Article |
| id | doaj-art-cfdb03d4e3ff456d9a0489e20e97a3b4 |
| institution | Matheson Library |
| issn | 1753-4267 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Innate Immunity |
| spelling | doaj-art-cfdb03d4e3ff456d9a0489e20e97a3b42025-06-27T21:03:26ZengSAGE PublishingInnate Immunity1753-42672025-06-013110.1177/17534259251352623Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammationSonghui Zhai0He Xu1Jianxin Xue2Lu Gan3Fang Gao4Lijuan Hu5 Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, China Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, China Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, ChinaObjective To research whether radiation-induced liver damage and fibrosis could be mitigated by resveratrol (RSV) and to elucidate its underlying mechanism. Methods A radiation-induced liver damage (RILD) model of murine was constructed. RSV was used as an intervention agent. The effects of RSV on inflammatory reaction, apoptosis, senescence, fibrosis, survival, and liver functions were detected by β-Gal, Sirius red, Masson's trichrome, and Tunnel staining using an automated biochemistry analyzer. The protein expression levels of P16 and P21 were detected by Western blot. Results RSV alleviated inflammatory injury of RILD mice. RSV decreased the serum pro-inflammatory cytokines of RILD mice. RSV alleviated radiation-induced hepatocellular senescence. The protein expression levels of P16 and P21 in RILD mice were decreased with RSV administration. RSV decreased the number of apoptotic cells in the early stage of RILD. RSV alleviated liver fibrosis and liver function in RILD mice. Conclusions RSV reduces RILD and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation.https://doi.org/10.1177/17534259251352623 |
| spellingShingle | Songhui Zhai He Xu Jianxin Xue Lu Gan Fang Gao Lijuan Hu Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation Innate Immunity |
| title | Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation |
| title_full | Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation |
| title_fullStr | Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation |
| title_full_unstemmed | Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation |
| title_short | Resveratrol reduces radiation-induced liver damage and fibrosis, and may be related to inhibiting cellular aging and reducing inflammation |
| title_sort | resveratrol reduces radiation induced liver damage and fibrosis and may be related to inhibiting cellular aging and reducing inflammation |
| url | https://doi.org/10.1177/17534259251352623 |
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