Progressive multifocal leukoencephalopathy: rheumatological aspects
Progressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency. It may develop as a complication in patients with systemic inflammatory rheumatic diseases (primarily in those with systemic lupus erythem...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2015-09-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/631 |
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| _version_ | 1839574174900682752 |
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| author | Boris Sergeevich Belov |
| author_facet | Boris Sergeevich Belov |
| author_sort | Boris Sergeevich Belov |
| collection | DOAJ |
| description | Progressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency. It may develop as a complication in patients with systemic inflammatory rheumatic diseases (primarily in those with systemic lupus erythematosus), including that during active antirheumatic therapy. The paper presents data on the etiology, epidemiology, and pathogenesis of the disease, characterizes its clinical presentation, highlights main approaches to its diagnosis, and gives current diagnostic criteria. A questionnaire used to monitor neurological status is shown. The paper emphasizes the importance of this monitoring, for early diagnosis and timely cessation of PML treatment with a drug, a potential trigger, are factors that influence prognosis to the utmost degree. |
| format | Article |
| id | doaj-art-cfaa13942dab47e08d83a72b94e07b5a |
| institution | Matheson Library |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-cfaa13942dab47e08d83a72b94e07b5a2025-08-04T14:00:33ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2015-09-01934910.14412/1996-7012-2015-3-4-91925Progressive multifocal leukoencephalopathy: rheumatological aspectsBoris Sergeevich Belov0V.A. Nasonova Research Institute of RheumatologyProgressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency. It may develop as a complication in patients with systemic inflammatory rheumatic diseases (primarily in those with systemic lupus erythematosus), including that during active antirheumatic therapy. The paper presents data on the etiology, epidemiology, and pathogenesis of the disease, characterizes its clinical presentation, highlights main approaches to its diagnosis, and gives current diagnostic criteria. A questionnaire used to monitor neurological status is shown. The paper emphasizes the importance of this monitoring, for early diagnosis and timely cessation of PML treatment with a drug, a potential trigger, are factors that influence prognosis to the utmost degree.https://mrj.ima-press.net/mrj/article/view/631progressive multifocal leukoencephalopathyclinical presentationdiagnosisrheumatic diseasesantirheumatic therapy |
| spellingShingle | Boris Sergeevich Belov Progressive multifocal leukoencephalopathy: rheumatological aspects Современная ревматология progressive multifocal leukoencephalopathy clinical presentation diagnosis rheumatic diseases antirheumatic therapy |
| title | Progressive multifocal leukoencephalopathy: rheumatological aspects |
| title_full | Progressive multifocal leukoencephalopathy: rheumatological aspects |
| title_fullStr | Progressive multifocal leukoencephalopathy: rheumatological aspects |
| title_full_unstemmed | Progressive multifocal leukoencephalopathy: rheumatological aspects |
| title_short | Progressive multifocal leukoencephalopathy: rheumatological aspects |
| title_sort | progressive multifocal leukoencephalopathy rheumatological aspects |
| topic | progressive multifocal leukoencephalopathy clinical presentation diagnosis rheumatic diseases antirheumatic therapy |
| url | https://mrj.ima-press.net/mrj/article/view/631 |
| work_keys_str_mv | AT borissergeevichbelov progressivemultifocalleukoencephalopathyrheumatologicalaspects |