Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

IntroductionBenign prostatic hyperplasia (BPH) is among the most common age-associated diseases in men. Prostatic immune cell infiltration is frequently observed with aging coincident with BPH; however, the contribution of age-related changes in immune cells to BPH is not clear. As T cells are the p...

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Main Authors: Meaghan M. Broman, Nadia A. Lanman, Renee E. Vickman, Gregory M. Cresswell, Harish Kothandaraman, Andree Kolliegbo, Juan Sebastian Paez Paez, Alexander P. Glaser, Brian T. Helfand, Gervaise Henry, Douglas W. Strand, Omar E. Franco, Simon W. Hayward, Timothy L. Ratliff
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
BPH
prostate
aging
inflammaging
T cells
granzyme K
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585446/full
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