Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain
Micro- and nanoscale photonic structures and devices play important roles in the development of advanced biophotonic systems, in particular, implantable light sources for optogenetic stimulations. In this paper, we numerically investigate silicon (Si) photonics based microprobes that can achieve mul...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2020-01-01
|
| Series: | IEEE Photonics Journal |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/9263293/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839644693935161344 |
|---|---|
| author | Roya Nazempour Qianyi Zhang Changbo Liu Xing Sheng |
| author_facet | Roya Nazempour Qianyi Zhang Changbo Liu Xing Sheng |
| author_sort | Roya Nazempour |
| collection | DOAJ |
| description | Micro- and nanoscale photonic structures and devices play important roles in the development of advanced biophotonic systems, in particular, implantable light sources for optogenetic stimulations. In this paper, we numerically investigate silicon (Si) photonics based microprobes that can achieve multi-site, multi-spectral optical excitation in the deep animal brain. On Si substrates, silicon nitride (Si<sub>3</sub>N<sub>4</sub>) based planar waveguides can deliver visible light in the deep tissue with low losses, and couple to grating emitters diffracting light in targeted brain regions. In our model, we combine near-field wave optic and far-field ray tracing simulations, showing that the designed photonic structures spectrally split blue, green and red photons into different locations in the tissue. Furthermore, by introducing dual grating components, photons at different wavelengths can be spatially separated at different depths. Therefore, these photonic probes can be used to selectively activate or inhibit specific neurons and nuclei, when expressing various corresponding light sensitive opsins. We anticipate that such device strategies can find wide applications in the design of advanced implantable photonic systems for neuroscience and neuroengineering. |
| format | Article |
| id | doaj-art-cf8ce2eec9144fb6ab68bd0e51d2b57a |
| institution | Matheson Library |
| issn | 1943-0655 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Photonics Journal |
| spelling | doaj-art-cf8ce2eec9144fb6ab68bd0e51d2b57a2025-07-01T23:56:55ZengIEEEIEEE Photonics Journal1943-06552020-01-011261710.1109/JPHOT.2020.30390159263293Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep BrainRoya Nazempour0Qianyi Zhang1Changbo Liu2Xing Sheng3https://orcid.org/0000-0002-8744-1700Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, ChinaSchool of Materials Science and Engineering and Hangzhou Innovation Institute, Beihang University, Beijing, ChinaDepartment of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, ChinaMicro- and nanoscale photonic structures and devices play important roles in the development of advanced biophotonic systems, in particular, implantable light sources for optogenetic stimulations. In this paper, we numerically investigate silicon (Si) photonics based microprobes that can achieve multi-site, multi-spectral optical excitation in the deep animal brain. On Si substrates, silicon nitride (Si<sub>3</sub>N<sub>4</sub>) based planar waveguides can deliver visible light in the deep tissue with low losses, and couple to grating emitters diffracting light in targeted brain regions. In our model, we combine near-field wave optic and far-field ray tracing simulations, showing that the designed photonic structures spectrally split blue, green and red photons into different locations in the tissue. Furthermore, by introducing dual grating components, photons at different wavelengths can be spatially separated at different depths. Therefore, these photonic probes can be used to selectively activate or inhibit specific neurons and nuclei, when expressing various corresponding light sensitive opsins. We anticipate that such device strategies can find wide applications in the design of advanced implantable photonic systems for neuroscience and neuroengineering.https://ieeexplore.ieee.org/document/9263293/Implantable devicesilicon photonicsoptogenetics |
| spellingShingle | Roya Nazempour Qianyi Zhang Changbo Liu Xing Sheng Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain IEEE Photonics Journal Implantable device silicon photonics optogenetics |
| title | Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain |
| title_full | Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain |
| title_fullStr | Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain |
| title_full_unstemmed | Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain |
| title_short | Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain |
| title_sort | design of silicon photonic structures for multi site multi spectral optogenetics in the deep brain |
| topic | Implantable device silicon photonics optogenetics |
| url | https://ieeexplore.ieee.org/document/9263293/ |
| work_keys_str_mv | AT royanazempour designofsiliconphotonicstructuresformultisitemultispectraloptogeneticsinthedeepbrain AT qianyizhang designofsiliconphotonicstructuresformultisitemultispectraloptogeneticsinthedeepbrain AT changboliu designofsiliconphotonicstructuresformultisitemultispectraloptogeneticsinthedeepbrain AT xingsheng designofsiliconphotonicstructuresformultisitemultispectraloptogeneticsinthedeepbrain |