Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study
Abstract Background Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional st...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-06-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
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| Online Access: | https://doi.org/10.1186/s43166-025-00340-6 |
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| author | Sahar Waheed El-Shafaey Abdel Wahab Shams El Deen EL Brashy Mohamed H. Faheem Noha Hosni Ibrahim |
| author_facet | Sahar Waheed El-Shafaey Abdel Wahab Shams El Deen EL Brashy Mohamed H. Faheem Noha Hosni Ibrahim |
| author_sort | Sahar Waheed El-Shafaey |
| collection | DOAJ |
| description | Abstract Background Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional study examined the association between the functional, clinical, and radiographic characteristics of primary knee osteoarthritis and both bone mineral density and serum vitamin D levels in postmenopausal women. Results There was a significant correlation between vitamin D levels and the knee osteoarthritis flare-up score (KOFUS) score (p = 0.005). A substantial association was found between bone mineral density as reflected by the T score and knee osteoarthritis flare-up score, WOMAC score, and Kellgren and Lawrence scores: p = 0.014, p < 0.05, and 0.001, respectively. A significant association was observed between bone mineral density (BMD) and the five-times sit-to-stand and 10-m walk speed tests. Conclusion Vitamin D deficiency has a significant impact on knee osteoarthritis severity and activity in postmenopausal women. A significant correlation exists between osteoporosis and flare-ups of knee osteoarthritis, along with both clinical and radiographic severity and functional status in postmenopausal women. |
| format | Article |
| id | doaj-art-cf8a83cfd2ec4e11a342e5fd2be28568 |
| institution | Matheson Library |
| issn | 2090-3235 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj-art-cf8a83cfd2ec4e11a342e5fd2be285682025-06-29T11:12:06ZengSpringerOpenEgyptian Rheumatology and Rehabilitation2090-32352025-06-0152111010.1186/s43166-025-00340-6Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional studySahar Waheed El-Shafaey0Abdel Wahab Shams El Deen EL Brashy1Mohamed H. Faheem2Noha Hosni Ibrahim3Rheumatology,Rehabilitation & Physical Medicine department-Faculty of Medicine., Benha UniversityRheumatology,Rehabilitation & Physical Medicine department-Faculty of Medicine., Benha UniversityDiagnostic Radiology department- Faculty of Medicine., Benha UniversityRheumatology,Rehabilitation & Physical Medicine department-Faculty of Medicine., Benha UniversityAbstract Background Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional study examined the association between the functional, clinical, and radiographic characteristics of primary knee osteoarthritis and both bone mineral density and serum vitamin D levels in postmenopausal women. Results There was a significant correlation between vitamin D levels and the knee osteoarthritis flare-up score (KOFUS) score (p = 0.005). A substantial association was found between bone mineral density as reflected by the T score and knee osteoarthritis flare-up score, WOMAC score, and Kellgren and Lawrence scores: p = 0.014, p < 0.05, and 0.001, respectively. A significant association was observed between bone mineral density (BMD) and the five-times sit-to-stand and 10-m walk speed tests. Conclusion Vitamin D deficiency has a significant impact on knee osteoarthritis severity and activity in postmenopausal women. A significant correlation exists between osteoporosis and flare-ups of knee osteoarthritis, along with both clinical and radiographic severity and functional status in postmenopausal women.https://doi.org/10.1186/s43166-025-00340-6OsteoarthritisPost-menopausalOsteoporosisVitamin D |
| spellingShingle | Sahar Waheed El-Shafaey Abdel Wahab Shams El Deen EL Brashy Mohamed H. Faheem Noha Hosni Ibrahim Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study Egyptian Rheumatology and Rehabilitation Osteoarthritis Post-menopausal Osteoporosis Vitamin D |
| title | Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study |
| title_full | Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study |
| title_fullStr | Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study |
| title_full_unstemmed | Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study |
| title_short | Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study |
| title_sort | relationship of vitamin d levels bone mineral density and primary knee osteoarthritis in postmenopausal women a cross sectional study |
| topic | Osteoarthritis Post-menopausal Osteoporosis Vitamin D |
| url | https://doi.org/10.1186/s43166-025-00340-6 |
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