Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs

The fatal motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of the phrenic MNs (phMNs) controlling the activity of the diaphragm, leading to death by respiratory failure. Human experimental models to study phMNs are lacking, hindering the unde...

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Bibliographic Details
Main Authors: Louise Thiry, Julien Sirois, Thomas Durcan, Stefano Stifani
Format: Article
Language:English
Published: Bio-protocol LLC 2025-07-01
Series:Bio-Protocol
Online Access:https://bio-protocol.org/en/bpdetail?id=5363&type=0
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