Combination of pregnancy and breast cancer
Breast cancer (BC) occupies the second place in terms of incidence and the first ranking place in terms of mortality among oncopathology in women. The article presents the current state of the problem of the combination of BC and pregnancy, the impact of pregnancy on the course and outcome of breast...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2023-10-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1141 |
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| author | A. L. Chernyshova A. A. Chernyakov E. Yu. Garbukov N. A. Tarabanovskaya Yu. M. Trushchuk O. S. Dil S. E. Krasilnikov A. V. Shumeykina |
| author_facet | A. L. Chernyshova A. A. Chernyakov E. Yu. Garbukov N. A. Tarabanovskaya Yu. M. Trushchuk O. S. Dil S. E. Krasilnikov A. V. Shumeykina |
| author_sort | A. L. Chernyshova |
| collection | DOAJ |
| description | Breast cancer (BC) occupies the second place in terms of incidence and the first ranking place in terms of mortality among oncopathology in women. The article presents the current state of the problem of the combination of BC and pregnancy, the impact of pregnancy on the course and outcome of breast oncopathology, as well as modern hypotheses for the development of breast cancer during pregnancy. It is shown that the current studies are quite contradictory and in many ways not accurate enough in methodology and materials. We present a clinical case of BC associated with pregnancy. The case is interesting from 2 positions: on the one hand, the patient’s tumor process is associated with pregnancy, on the other hand, there is a very rare combination of HER2/neu- and BRCA1-positive status.According to the presented literature data and our own data, it was concluded that the treatment of patients with BC during pregnancy is a difficult task and is often accompanied by tumor progression, despite the standard treatment regimens. Undoubtedly, this group of patients needs to develop new methodological approaches to antitumor treatment based on a deep analysis of the molecular genetic characteristics of the tumor, the hormonal background in general, and its effect on the tumor process during pregnancy. Such a personalized approach will improve the results of treatment of young patients with BC during pregnancy. |
| format | Article |
| id | doaj-art-cd70d66145a44e65a86bb94e181b60da |
| institution | Matheson Library |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-cd70d66145a44e65a86bb94e181b60da2025-08-04T14:33:42ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272023-10-01193859110.17650/1994-4098-2023-19-3-85-91816Combination of pregnancy and breast cancerA. L. Chernyshova0A. A. Chernyakov1E. Yu. Garbukov2N. A. Tarabanovskaya3Yu. M. Trushchuk4O. S. Dil5S. E. Krasilnikov6A. V. Shumeykina7Oncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesOncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesOncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesOncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesOncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesOncology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesE.N. Meshalkin National Medical Research Center, Ministry of Health of RussiaE.N. Meshalkin National Medical Research Center, Ministry of Health of RussiaBreast cancer (BC) occupies the second place in terms of incidence and the first ranking place in terms of mortality among oncopathology in women. The article presents the current state of the problem of the combination of BC and pregnancy, the impact of pregnancy on the course and outcome of breast oncopathology, as well as modern hypotheses for the development of breast cancer during pregnancy. It is shown that the current studies are quite contradictory and in many ways not accurate enough in methodology and materials. We present a clinical case of BC associated with pregnancy. The case is interesting from 2 positions: on the one hand, the patient’s tumor process is associated with pregnancy, on the other hand, there is a very rare combination of HER2/neu- and BRCA1-positive status.According to the presented literature data and our own data, it was concluded that the treatment of patients with BC during pregnancy is a difficult task and is often accompanied by tumor progression, despite the standard treatment regimens. Undoubtedly, this group of patients needs to develop new methodological approaches to antitumor treatment based on a deep analysis of the molecular genetic characteristics of the tumor, the hormonal background in general, and its effect on the tumor process during pregnancy. Such a personalized approach will improve the results of treatment of young patients with BC during pregnancy.https://ojrs.abvpress.ru/ojrs/article/view/1141pregnancybreast cancerprognosistumor process |
| spellingShingle | A. L. Chernyshova A. A. Chernyakov E. Yu. Garbukov N. A. Tarabanovskaya Yu. M. Trushchuk O. S. Dil S. E. Krasilnikov A. V. Shumeykina Combination of pregnancy and breast cancer Опухоли женской репродуктивной системы pregnancy breast cancer prognosis tumor process |
| title | Combination of pregnancy and breast cancer |
| title_full | Combination of pregnancy and breast cancer |
| title_fullStr | Combination of pregnancy and breast cancer |
| title_full_unstemmed | Combination of pregnancy and breast cancer |
| title_short | Combination of pregnancy and breast cancer |
| title_sort | combination of pregnancy and breast cancer |
| topic | pregnancy breast cancer prognosis tumor process |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1141 |
| work_keys_str_mv | AT alchernyshova combinationofpregnancyandbreastcancer AT aachernyakov combinationofpregnancyandbreastcancer AT eyugarbukov combinationofpregnancyandbreastcancer AT natarabanovskaya combinationofpregnancyandbreastcancer AT yumtrushchuk combinationofpregnancyandbreastcancer AT osdil combinationofpregnancyandbreastcancer AT sekrasilnikov combinationofpregnancyandbreastcancer AT avshumeykina combinationofpregnancyandbreastcancer |