Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism
In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2017-06-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/593 |
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| author | N. A. Stepanova Kh. M. Galimzyanov B. I. Kantemirova |
| author_facet | N. A. Stepanova Kh. M. Galimzyanov B. I. Kantemirova |
| author_sort | N. A. Stepanova |
| collection | DOAJ |
| description | In 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting. |
| format | Article |
| id | doaj-art-cd0cf89c7c9e4c86a9465d1c23e30fad |
| institution | Matheson Library |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-cd0cf89c7c9e4c86a9465d1c23e30fad2025-08-04T14:25:43ZrusJournal InfectologyЖурнал инфектологии2072-67322017-06-0192131610.22625/2072-6732-2017-9-2-13-16549Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphismN. A. Stepanova0Kh. M. Galimzyanov1B. I. Kantemirova2Astrakhan State Medical UniversityAstrakhan State Medical UniversityAstrakhan State Medical UniversityIn 178 patients with different clinical forms of pulmonary tuberculosis carried out pharmacogenetic testing to determine gene polymorphism glutathione S-transferase system (GSTM1, GSTT1). Estimated the severity and duration of clinical manifestations of the syndrome of intoxication, depending on the gene polymorphism of glutathione S-transferase system (GSTM1, GSTT1). It was found that the combination of “zero” to develop genotypes GSTM1 and GSTT1 enzyme is a predictor of the severity and duration of symptoms of intoxication persisting.https://journal.niidi.ru/jofin/article/view/593intoxicationglutathione s-transferase gene polymorphismintoxication. pulmonary tuberculosis |
| spellingShingle | N. A. Stepanova Kh. M. Galimzyanov B. I. Kantemirova Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism Журнал инфектологии intoxication glutathione s-transferase gene polymorphism intoxication. pulmonary tuberculosis |
| title | Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| title_full | Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| title_fullStr | Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| title_full_unstemmed | Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| title_short | Intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| title_sort | intoxication syndrome in patients with pulmonary tuberculosis in relation to the system glutathione transferase gene polymorphism |
| topic | intoxication glutathione s-transferase gene polymorphism intoxication. pulmonary tuberculosis |
| url | https://journal.niidi.ru/jofin/article/view/593 |
| work_keys_str_mv | AT nastepanova intoxicationsyndromeinpatientswithpulmonarytuberculosisinrelationtothesystemglutathionetransferasegenepolymorphism AT khmgalimzyanov intoxicationsyndromeinpatientswithpulmonarytuberculosisinrelationtothesystemglutathionetransferasegenepolymorphism AT bikantemirova intoxicationsyndromeinpatientswithpulmonarytuberculosisinrelationtothesystemglutathionetransferasegenepolymorphism |