Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study
Background The haemostatic system plays a role in development of valvular vegetations and systemic activation of coagulation, contributing to both thrombosis and consumption coagulopathy. Patients with infective endocarditis undergoing valvular surgery pose unique challenges to the surgical team. Ro...
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SAGE Publishing
2025-07-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296251356205 |
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| author | Stanislaw Vander Zwaag MD, DESAIC Imre Kukel MD, PhD Kinga Towarek-Nocon MD Jens Fassl MD, PhD, FASE |
| author_facet | Stanislaw Vander Zwaag MD, DESAIC Imre Kukel MD, PhD Kinga Towarek-Nocon MD Jens Fassl MD, PhD, FASE |
| author_sort | Stanislaw Vander Zwaag MD, DESAIC |
| collection | DOAJ |
| description | Background The haemostatic system plays a role in development of valvular vegetations and systemic activation of coagulation, contributing to both thrombosis and consumption coagulopathy. Patients with infective endocarditis undergoing valvular surgery pose unique challenges to the surgical team. Rotational thromboelastometry (ROTEM), a point-of-care viscoelastic clotting test, can help assess coagulation and guide therapy. This retrospective propensity score-matched study explores ROTEM's distinctive features in endocarditis patients compared to others undergoing cardiac surgery. Materials and Methods A retrospective analysis was performed on patients undergoing valvular surgery between May 31, 2022, and August 31, 2024. ROTEM assessments were conducted during extracorporeal circulation and post-heparin reversal. The study group consisted of patients with endocarditis, while propensity score matching created a control group of patients without endocarditis. The primary outcome was on-pump ROTEM results; secondary outcomes included utilisation of red blood cells (pRBC), fibrinogen concentrate (FC), prothrombin complex concentrate (PCC), fresh frozen plasma (FFP), and platelets. Results In both groups (23 patients each), endocarditis patients had prolonged EXTEM clotting times (136 vs 96 s, P = .001) and higher FIBTEM-A5 clot firmness (19 vs 13 mm, P = .012). They required more PCC (3000 vs 2500 units, P = .014), while transfusions of platelets ( P = .281), FFP ( P = 1.000), and FC ( P = .109) did not differ significantly. Conclusion Endocarditis patients demonstrate distinct viscoelastic profiles with prolonged clotting times and increased clot firmness, necessitating greater PCC supplementation. Further research is warranted to optimise ROTEM target values to balance bleeding and thrombotic risks. |
| format | Article |
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| institution | Matheson Library |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-ccc82c49ff1a4dfc8bf8dfdce4b51e7f2025-07-04T09:03:36ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-07-013110.1177/10760296251356205Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational StudyStanislaw Vander Zwaag MD, DESAIC0Imre Kukel MD, PhD1Kinga Towarek-Nocon MD2Jens Fassl MD, PhD, FASE3 Department of Cardiac Anesthesiology, Medical Faculty and Heart Center Dresden, , Dresden, Germany Department of Cardiac Anesthesiology, Medical Faculty and Heart Center Dresden, , Dresden, Germany Department of Anaesthesiology, Intensive Care, Emergency-, Pain- and Palliative Medicine, , Radebeul, Germany Department of Cardiac Anesthesiology, Medical Faculty and Heart Center Dresden, , Dresden, GermanyBackground The haemostatic system plays a role in development of valvular vegetations and systemic activation of coagulation, contributing to both thrombosis and consumption coagulopathy. Patients with infective endocarditis undergoing valvular surgery pose unique challenges to the surgical team. Rotational thromboelastometry (ROTEM), a point-of-care viscoelastic clotting test, can help assess coagulation and guide therapy. This retrospective propensity score-matched study explores ROTEM's distinctive features in endocarditis patients compared to others undergoing cardiac surgery. Materials and Methods A retrospective analysis was performed on patients undergoing valvular surgery between May 31, 2022, and August 31, 2024. ROTEM assessments were conducted during extracorporeal circulation and post-heparin reversal. The study group consisted of patients with endocarditis, while propensity score matching created a control group of patients without endocarditis. The primary outcome was on-pump ROTEM results; secondary outcomes included utilisation of red blood cells (pRBC), fibrinogen concentrate (FC), prothrombin complex concentrate (PCC), fresh frozen plasma (FFP), and platelets. Results In both groups (23 patients each), endocarditis patients had prolonged EXTEM clotting times (136 vs 96 s, P = .001) and higher FIBTEM-A5 clot firmness (19 vs 13 mm, P = .012). They required more PCC (3000 vs 2500 units, P = .014), while transfusions of platelets ( P = .281), FFP ( P = 1.000), and FC ( P = .109) did not differ significantly. Conclusion Endocarditis patients demonstrate distinct viscoelastic profiles with prolonged clotting times and increased clot firmness, necessitating greater PCC supplementation. Further research is warranted to optimise ROTEM target values to balance bleeding and thrombotic risks.https://doi.org/10.1177/10760296251356205 |
| spellingShingle | Stanislaw Vander Zwaag MD, DESAIC Imre Kukel MD, PhD Kinga Towarek-Nocon MD Jens Fassl MD, PhD, FASE Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study Clinical and Applied Thrombosis/Hemostasis |
| title | Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study |
| title_full | Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study |
| title_fullStr | Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study |
| title_full_unstemmed | Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study |
| title_short | Distinctive Features of Rotational Thromboelastometry in Patients with Infective Endocarditis Undergoing on-Pump Cardiac Surgery: A Retrospective Propensity Score-matched Observational Study |
| title_sort | distinctive features of rotational thromboelastometry in patients with infective endocarditis undergoing on pump cardiac surgery a retrospective propensity score matched observational study |
| url | https://doi.org/10.1177/10760296251356205 |
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