Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy
Sepsis-associated encephalopathy (SAE) represents the most prevalent neurological complication of sepsis and is frequently linked to unfavorable patient outcomes. This study aimed to evaluate the prognostic significance of serum Netrin-1, neuron-specific enolase (NSE), and S100β levels in patients...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-07-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12215 |
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| author | Bo Zhang Qiong Wu Jing Wu |
| author_facet | Bo Zhang Qiong Wu Jing Wu |
| author_sort | Bo Zhang |
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Sepsis-associated encephalopathy (SAE) represents the most prevalent neurological complication of sepsis and is frequently linked to unfavorable patient outcomes. This study aimed to evaluate the prognostic significance of serum Netrin-1, neuron-specific enolase (NSE), and S100β levels in patients diagnosed with SAE. A retrospective analysis was performed on 120 SAE patients, measuring serum levels of Netrin-1, NSE, and S100β and correlating these with Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores. Independent risk factors for short-term mortality were identified, and the predictive values of these biomarkers were assessed both individually and in combination. Kaplan-Meier analysis was utilized to compare short-term mortality based on biomarker levels. Netrin-1 was found to be significantly downregulated, while NSE and S100β levels were upregulated in SAE patients. Lower levels of Netrin-1, alongside higher levels of NSE and S100β, correlated with elevated APACHE-II scores and increased short-term mortality. Multivariate analysis confirmed that all three biomarkers serve as independent predictors of short-term mortality. The combined assessment of Netrin-1, NSE, and S100β demonstrated superior prognostic value compared to individual biomarker. Therefore, serum levels of Netrin-1, NSE, and S100β are closely associated with the severity of brain injury in SAE and serve as effective predictors of short-term mortality, enhancing prognostic accuracy in clinical practice.
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| format | Article |
| id | doaj-art-cc7f9dd879a44d1ca87e6047f3713f1d |
| institution | Matheson Library |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
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| series | Biomolecules & Biomedicine |
| spelling | doaj-art-cc7f9dd879a44d1ca87e6047f3713f1d2025-07-28T16:03:50ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-07-0110.17305/bb.2025.12215Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathyBo Zhang0Qiong Wu1Jing Wu2Department of Neurosurgery, Shijiazhuang People's Hospital, Shijiazhuang, ChinaDepartment of Neurosurgery, Hebei Medical University Second Hospital, Shijiazhuang, ChinaDepartment of Function, Hebei Provincial Traditional Chinese Medicine Hospital, Shijiazhuang, China Sepsis-associated encephalopathy (SAE) represents the most prevalent neurological complication of sepsis and is frequently linked to unfavorable patient outcomes. This study aimed to evaluate the prognostic significance of serum Netrin-1, neuron-specific enolase (NSE), and S100β levels in patients diagnosed with SAE. A retrospective analysis was performed on 120 SAE patients, measuring serum levels of Netrin-1, NSE, and S100β and correlating these with Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores. Independent risk factors for short-term mortality were identified, and the predictive values of these biomarkers were assessed both individually and in combination. Kaplan-Meier analysis was utilized to compare short-term mortality based on biomarker levels. Netrin-1 was found to be significantly downregulated, while NSE and S100β levels were upregulated in SAE patients. Lower levels of Netrin-1, alongside higher levels of NSE and S100β, correlated with elevated APACHE-II scores and increased short-term mortality. Multivariate analysis confirmed that all three biomarkers serve as independent predictors of short-term mortality. The combined assessment of Netrin-1, NSE, and S100β demonstrated superior prognostic value compared to individual biomarker. Therefore, serum levels of Netrin-1, NSE, and S100β are closely associated with the severity of brain injury in SAE and serve as effective predictors of short-term mortality, enhancing prognostic accuracy in clinical practice. https://www.bjbms.org/ojs/index.php/bjbms/article/view/12215Sepsis-associated encephalopathyNetrin-1neuron-specific enolaseS100βAPACHE-II scoresequential/sepsis-related organ failure assessment score |
| spellingShingle | Bo Zhang Qiong Wu Jing Wu Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy Biomolecules & Biomedicine Sepsis-associated encephalopathy Netrin-1 neuron-specific enolase S100β APACHE-II score sequential/sepsis-related organ failure assessment score |
| title | Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy |
| title_full | Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy |
| title_fullStr | Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy |
| title_full_unstemmed | Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy |
| title_short | Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy |
| title_sort | association of serum netrin 1 nse and s100β with brain injury severity and prognosis in patients with sepsis associated encephalopathy |
| topic | Sepsis-associated encephalopathy Netrin-1 neuron-specific enolase S100β APACHE-II score sequential/sepsis-related organ failure assessment score |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12215 |
| work_keys_str_mv | AT bozhang associationofserumnetrin1nseands100bwithbraininjuryseverityandprognosisinpatientswithsepsisassociatedencephalopathy AT qiongwu associationofserumnetrin1nseands100bwithbraininjuryseverityandprognosisinpatientswithsepsisassociatedencephalopathy AT jingwu associationofserumnetrin1nseands100bwithbraininjuryseverityandprognosisinpatientswithsepsisassociatedencephalopathy |