Oxidized Low-Density Lipoprotein as a Potential Target for Enhancing Immune Checkpoint Inhibitor Therapy in Microsatellite-Stable Colorectal Cancer

Oxidized Low-Density Lipoprotein as a Potential Target for Enhancing Immune Checkpoint Inhibitor Therapy in Microsatellite-Stable Colorectal Cancer

Oxidized low-density lipoprotein (oxLDL) exhibits differential expression in microsatellite-stable (MSS) and microsatellite instability-high (MSI) colorectal cancer (CRC), highlighting its potential therapeutic role in immune checkpoint inhibitor (ICI) resistance in MSS CRC. Elevated oxLDL levels in...

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Bibliographic Details
Main Authors: Xiaochun Zhang, Xiaorui Ye, Heiying Jin
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antioxidants
Subjects:
oxidized low-density lipoprotein
microsatellite-stable colorectal cancer
immune checkpoint inhibitors
tumor microenvironment
metabolic reprogramming
immunosuppression
Online Access:https://www.mdpi.com/2076-3921/14/6/726
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