Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantation

Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantation

BackgroundAlthough our team has demonstrated the antidepressant effect of Gardeniae Fructus oil (OGF) in the early stages, the mechanism of whether OGF works by regulating the gut microbiota is not clear. This study aims to elucidate OGF’s gut-brain axis mechanism in depression.MethodsChronic unpred...

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Bibliographic Details
Main Authors: Man Han, Yujing Zhou, Xinyu Gao, Xixi Cheng, Ling Deng, Shilin Ji, Zhengheng Li, Yu Cai, Chunchao Yan, Yunzhong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
Gardeniae Fructus oil
depression
chronic unpredictable mild stress
fecal microbiota transplantation
transcriptomics
gut-brain axis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1635897/full
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