OCULAR SURFACE’S DISORDERS IN GLAUCOMA PATIENTS TREATED WITH LONG INSTILLATION OF BETA BLOCKERS WITH PRESERVATIVES
The study included 30 patients with glaucomatous optic neuropathy (GON) with intraocular pressure stabilized by the instillation of b-blockers with a preservative and complaints of discomfort in the eye (1 group), 20 patients with newly diagnosed GON (2-group). Performed: a standard research; a modi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2017-07-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/761 |
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| Summary: | The study included 30 patients with glaucomatous optic neuropathy (GON) with intraocular pressure stabilized by the instillation of b-blockers with a preservative and complaints of discomfort in the eye (1 group), 20 patients with newly diagnosed GON (2-group). Performed: a standard research; a modified morphological examination with the calculation of the mucin production factors (MPF) and tissue entropy (CHP), a multi-cytokin study of the tear liquid. 1st group patients showed signs of the syndrome of «dry eye» (SDE), including a combined lipid-, water-, mucin-deficit; epitheliopathy of conjunctiva (76,7%), conjunctiva and cornea(23,3%), marked reduction of the MPF at a moderate decrease in the number of goblet cells, and the CHP increase, a higher level of pro-inflammatory Th1 as well as of Th2 cytokins. The obtained data is necessary for the development of sound therapy options of the SDE of this type. |
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| ISSN: | 1608-6228 2541-9544 |