Concentration-Dependent Pleiotropic Effects of Thymosin Beta4 and Cofilin on the Migratory Activity of Carcinoma Cells

QR Code

Concentration-Dependent Pleiotropic Effects of Thymosin Beta4 and Cofilin on the Migratory Activity of Carcinoma Cells

Background/Objectives: Tumor cell migration depends on the actin cytoskeleton modified by actin-binding proteins (ABPs). Overexpression of cofilin or thymosin beta4 (Tß4) has been correlated with an increase or decrease in their migratory activity, respectively. Methods: Immunostaining of tumor cell...

Full description

Saved in:

Bibliographic Details
Main Authors:	Abdulatif Al Haj, Kamila Ćwikłowska, Antonina Joanna Mazur, Beate Brand-Saberi, Ewald Hannappel, Hans Georg Mannherz
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	International Journal of Translational Medicine
Subjects:	actin carcinoma cells cofilin integrin-linked kinase thymosin beta
Online Access:	https://www.mdpi.com/2673-8937/5/2/16
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Matrix stiffness regulates the behavior of glioma cells by altering the expression of Cofilin-1
by: Zongmei Ding, et al.
Published: (2025-09-01)

Mechanical signaling regulates vascular smooth muscle cell adaptation in aging
by: Amin Mohajeri, et al.
Published: (2025-07-01)

The Prognostic Significance of TMSB4X in Glioma Patients
by: Li S, et al.
Published: (2025-06-01)

Actin isoforms and neoplastic transformation
by: V. B. Dugina, et al.
Published: (2017-04-01)

Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes
by: Dylan A Valencia, et al.
Published: (2025-07-01)

MORPHOLOGICAL AND EXPRESSION FEATURES OF DUCTAL PANCREATIC ADENOCARCINOMA
by: Yu. Yu. Rakina, et al.
Published: (2017-09-01)

Integrins and pulmonary fibrosis: Pathogenic roles and therapeutic opportunities
by: Zhangyang Bi, et al.
Published: (2025-06-01)

Field Cancerization Treatment with Tirbanibulin 1% Ointment: Results in Real-World Practice
by: Francisco Vílchez-Márquez, et al.
Published: (2025-07-01)

Perforating Granuloma Annulare with Cysts and Comedones
by: Enric Piqué-Duran, et al.
Published: (2025-05-01)

Expression levels of β1, β3 integrins and MMP2 and features of morphological heterogeneity of pancreatic ductal adenocarcinoma associated with distant metastasis
by: Yu. Yu. Rakina, et al.
Published: (2023-05-01)

Cortical Actin Depolymerisation in 3D Cell Culture Enhances Extracellular Vesicle Secretion and Therapeutic Effects
by: Zhen Yang, et al.
Published: (2025-06-01)

Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5
by: Yuji Yamada, et al.
Published: (2025-09-01)

In Silico Prediction of Tetrastatin-Derived Peptide Interactions with αvβ3 and α5β1 Integrins
by: Vivien Paturel, et al.
Published: (2025-06-01)

Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma
by: Erica Routila, et al.
Published: (2025-05-01)

Correction: High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1
by: Roberta Lucianò, et al.
Published: (2025-06-01)

High-grade non-muscle invasive urothelial carcinoma in dogs and humans share specific expression of integrin α5β1
by: Roberta Lucianò, et al.
Published: (2025-05-01)

Changing of expression actinbinding proteins in the kidney under dehydration
by: I. I. Khegay
Published: (2018-04-01)

Exploring the maternal inheritance transmitted by the oocyte to its progeny
by: Verlhac, Marie-Hélène
Published: (2024-06-01)

Actin dynamics and the elasticity of cytoskeletal networks
Published: (2009-09-01)

A Case Report of Generalization of Localized Actinic Granuloma, an Unusual Diffuse Presentation Not Responding to Tofacitinib
by: Saman Al‐Zahawi, et al.
Published: (2025-07-01)

Association of integrin expression in tumor tissue with hematogenic metastasis of breast cancer
by: M. V. Zavyalova, et al.
Published: (2024-01-01)

Integrin profile of circulating tumour cells in breast cancer patients
by: E. S. Grigoryeva, et al.
Published: (2024-09-01)

Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets
by: Alessandro Bruschi, et al.
Published: (2025-05-01)

Current state of methods of correction of involutional changes of skin and the place of photodynamic therapy among them
by: M. A. Beimanova, et al.
Published: (2020-02-01)

Real-World Efficacy of Tirbanibulin in Actinic Keratosis Treatment: Expert Consensus and Clinical Insights
by: Marco Ardigò, et al.
Published: (2025-07-01)

Association of Gene Variants of Plasmic (<i>FGB</i> -455 G>A (rs1800790), <i>F2</i> 20210 G>A (rs1799963), <i>F5</i> 1691 G>A (rs6025), <i>F7</i> 10976 G>A (rs6046), <i>F13</i> G>T (rs5985)), Thrombocytic (<i>ITGA2</i> 807 C>T (rs1126643), <i>ITGB3</i> 1565 T>C (rs5918)), Fibrinolytic (<i>PAI-1</i> -675 5G>4G (rs1799889)) Hemostasis Components with Arterial or Venous Thrombosis in Newborns: Case-Controlled Study
by: Olesia A. Filippova, et al.
Published: (2020-11-01)

Features of integrin subunit β4 expression depending on clinical and morphological parameters of breast cancer
by: M. V. Zavyalova, et al.
Published: (2025-04-01)

Salmonella YrbD protein mediates invasion into the host by interacting with β2 integrin
by: Jun Cao, et al.
Published: (2025-03-01)

Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients
by: Maha K. Al-Mishrey
Published: (2023-02-01)

Bioactive Factors Isolated and Purified from Bovine Colostrum Can Restore Extracellular Matrix Under Degradation by Metalloproteinases
by: Federica Coppa, et al.
Published: (2025-04-01)

STUDY OF SODIUM, POTASSIUM, AND CALCIUM SALTS INFLUENCE ON PROTEIN STABILITY BY DIFFERENTIAL SCANNING CALORIMETRY
by: E. K. Tunieva, et al.
Published: (2016-06-01)

Our journey with François Gros
by: Butler-Browne, Gillian, et al.
Published: (2023-12-01)

Alpha Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma: a Case Report
by: Swati Roy, et al.
Published: (2013-02-01)

Role of Tropomodulins in brain physiology and pathology
by: Chuan Hong, et al.
Published: (2025-09-01)

Plant strategy to adapt to life in water: peculiarities of root system organization in Sagittaria sagittifolia and Alisma plantago-aquatica (Alismataceae)
by: Ovcharenko Yu., et al.
Published: (2025-06-01)

DISSEMINATED SUPERFICIAL ACTINIC POROKERATOSIS: A CLINICAL CASE REPORT
by: L. A. Anisimova, et al.
Published: (2014-03-01)

Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis
by: Victoria Kuta, et al.
Published: (2025-04-01)

A Bibliometric Analysis and Visualization of Research Trends and Hotspots in Actinic Keratosis Based on Web of Science
by: Cheng Z, et al.
Published: (2025-06-01)

CD11b Blockade Ameliorates Myocardial Ischemia/Reperfusion Injury by Reducing Neutrophil and Monocyte Infiltration
by: Peng Fu, et al.
Published: (2025-07-01)

Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates
by: Marie Amalie Balamurugan, et al.
Published: (2025-07-01)