A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer

IntroductionClinical workflows to analyze variants of unknown significance (VUSs) found in clinical next generation sequencing (NGS) are labor intensive, requiring manual analysis of published data for each variant. There is a strong need for tools and resources that provide a consistent way to anal...

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Bibliographic Details
Main Authors: Amith Rangarajan, Ilona Sviezhentseva, Emma Gunderson, Yana Pikman, Matthew P. Jacobson, Beth Apsel Winger
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
cancer
targeted therapy
molecular pathology
next generation sequencing
kinases
structural biology
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1599389/full
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