Ovarial function in pts with systemic lupus erythematosus

Objective. To assess ovarian function and its changes during therapy with cyclophosphan (CPh) in pts with systemic lupus erythematosus (SLE). Material and Methods. 44 pts with SLE aged 16 to 45 years with intact menstrual cycle were examined. 18 from them had received CPh earlier (mean cumulative do...

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Main Authors: S Sh Sliabanova, Z S Alekberova, I I Guzov, L P Ananyeva
Format: Article
Language:Russian
Published: IMA PRESS LLC 2004-06-01
Series:Научно-практическая ревматология
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Online Access:https://rsp.mediar-press.net/rsp/article/view/1298
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author S Sh Sliabanova
Z S Alekberova
I I Guzov
L P Ananyeva
author_facet S Sh Sliabanova
Z S Alekberova
I I Guzov
L P Ananyeva
author_sort S Sh Sliabanova
collection DOAJ
description Objective. To assess ovarian function and its changes during therapy with cyclophosphan (CPh) in pts with systemic lupus erythematosus (SLE). Material and Methods. 44 pts with SLE aged 16 to 45 years with intact menstrual cycle were examined. 18 from them had received CPh earlier (mean cumulative dose 5,7 g), 26 had been never treated with CPh. Mean age, disease duration and activity (according to SLEDAI) as well as glucocorticoid (GC) doses were similar in both groups. Blood sex hormones - follicle-stimulating hormone (FSH), lutropin (LT), prolactin, estradiol, progesterone were tested with immune-enzyme assay. Each pt was examined by a gynaecologist, pelvis minor ultrasonography was performed, basal temperature was measured during 3 months Results. CPh treated pts had lower mean progesterone levels but higher FSH and LT than pts that had not received CPh. Intensity of these changes depended on cumulative dose of CPh and age of pts. Failure of menstrual cycle lutein phase was found with similar frequency in both groups and achieved in average 63%. Oligomenorrhea and more than twofold menstrual cycle shortening were present more frequently in pts treated with CPh (p<0,05). Conclusion. Treatment with CPh increase risk of ovarian dysfunction in pts with SLE. Failure of menstrual cycle lutein phase does not exclude autoimmune genesis of oophoritis in SLE.
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spelling doaj-art-cbbc2d0ef373419cb15f6956f5cef6202025-08-04T17:03:47ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922004-06-014234910.14412/1995-4484-2004-14691238Ovarial function in pts with systemic lupus erythematosusS Sh SliabanovaZ S AlekberovaI I GuzovL P AnanyevaObjective. To assess ovarian function and its changes during therapy with cyclophosphan (CPh) in pts with systemic lupus erythematosus (SLE). Material and Methods. 44 pts with SLE aged 16 to 45 years with intact menstrual cycle were examined. 18 from them had received CPh earlier (mean cumulative dose 5,7 g), 26 had been never treated with CPh. Mean age, disease duration and activity (according to SLEDAI) as well as glucocorticoid (GC) doses were similar in both groups. Blood sex hormones - follicle-stimulating hormone (FSH), lutropin (LT), prolactin, estradiol, progesterone were tested with immune-enzyme assay. Each pt was examined by a gynaecologist, pelvis minor ultrasonography was performed, basal temperature was measured during 3 months Results. CPh treated pts had lower mean progesterone levels but higher FSH and LT than pts that had not received CPh. Intensity of these changes depended on cumulative dose of CPh and age of pts. Failure of menstrual cycle lutein phase was found with similar frequency in both groups and achieved in average 63%. Oligomenorrhea and more than twofold menstrual cycle shortening were present more frequently in pts treated with CPh (p<0,05). Conclusion. Treatment with CPh increase risk of ovarian dysfunction in pts with SLE. Failure of menstrual cycle lutein phase does not exclude autoimmune genesis of oophoritis in SLE.https://rsp.mediar-press.net/rsp/article/view/1298systemic lupus erythematosusovarian functioncyclophosphan
spellingShingle S Sh Sliabanova
Z S Alekberova
I I Guzov
L P Ananyeva
Ovarial function in pts with systemic lupus erythematosus
Научно-практическая ревматология
systemic lupus erythematosus
ovarian function
cyclophosphan
title Ovarial function in pts with systemic lupus erythematosus
title_full Ovarial function in pts with systemic lupus erythematosus
title_fullStr Ovarial function in pts with systemic lupus erythematosus
title_full_unstemmed Ovarial function in pts with systemic lupus erythematosus
title_short Ovarial function in pts with systemic lupus erythematosus
title_sort ovarial function in pts with systemic lupus erythematosus
topic systemic lupus erythematosus
ovarian function
cyclophosphan
url https://rsp.mediar-press.net/rsp/article/view/1298
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AT zsalekberova ovarialfunctioninptswithsystemiclupuserythematosus
AT iiguzov ovarialfunctioninptswithsystemiclupuserythematosus
AT lpananyeva ovarialfunctioninptswithsystemiclupuserythematosus