Germline encoded residues dominate the interaction of a human monoclonal antibody with decorin binding protein A of Borrelia burgdorferi

During the course of Lyme disease, humans mount a robust and sustained antibody response against dozens of Borrelia burgdorferi outer surface lipoproteins. Identifying which antibodies are associated with spirochete clearance and disease resolution is of paramount importance in therapeutic developme...

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Main Authors: Michael J. Rudolph, Beatrice M. Muriuki, Yang Chen, David J. Vance, Clint Vorauer, Carol Lyn Piazza, Grace Freeman-Gallant, Rachel M. Golonka, Gianna Mirabile, Miklos Guttman, Lisa A. Cavacini, Nicholas J. Mantis
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1611828/full
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