High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies.
<h4>Objective</h4>Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0056864 |
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| author | Qin Lv Xian-Fang Meng Fang-Fang He Shan Chen Hua Su Jing Xiong Pan Gao Xiu-Juan Tian Jian-She Liu Zhong-Hua Zhu Kai Huang Chun Zhang |
| author_facet | Qin Lv Xian-Fang Meng Fang-Fang He Shan Chen Hua Su Jing Xiong Pan Gao Xiu-Juan Tian Jian-She Liu Zhong-Hua Zhu Kai Huang Chun Zhang |
| author_sort | Qin Lv |
| collection | DOAJ |
| description | <h4>Objective</h4>Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.<h4>Design and methods</h4>We conducted a systematic literature search of the PubMed database through April 2012. Prospective cohort studies were included in meta-analysis that reported the multivariate adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) for the association between serum uric acid and risk of type 2 diabetes. We used both fix-effects and random-effects models to calculate the overall effect estimate. The heterogeneity across studies was tested by both Q statistic and I(2) statistic. Begg's funnel plot and Egger's regression test were used to assess the potential publication bias.<h4>Results</h4>We retrieved 7 eligible articles derived from 8 prospective cohort studies, involving a total of 32016 participants and 2930 incident type 2 diabetes. The combined RR of developing type 2 diabetes for the highest category of serum uric acid level compared with the lowest was 1.56(95% CI, 1.39-1.76). Dose-response analysis showed the risk of type 2 diabetes was increased by 6% per 1 mg/dl increment in serum uric acid level (RR 1.06, 95% CI: 1.04-1.07). The result from each subgroup showed a significant association between serum uric acid and risk of type 2 diabetes. In sensitive analysis, the combined RR was consistent every time omitting any one study. Little evidence of heterogeneity and publication bias was observed.<h4>Conclusions</h4>Our meta-analysis of prospective cohort studies provided strong evidence that high level of serum uric acid is independent of other established risk factors, especially metabolic syndrome components, for developing type 2 diabetes in middle-aged and older people. |
| format | Article |
| id | doaj-art-cbad24d70b3945b6af9c8303ab5c9c08 |
| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-cbad24d70b3945b6af9c8303ab5c9c082025-07-12T05:31:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5686410.1371/journal.pone.0056864High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies.Qin LvXian-Fang MengFang-Fang HeShan ChenHua SuJing XiongPan GaoXiu-Juan TianJian-She LiuZhong-Hua ZhuKai HuangChun Zhang<h4>Objective</h4>Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies.<h4>Design and methods</h4>We conducted a systematic literature search of the PubMed database through April 2012. Prospective cohort studies were included in meta-analysis that reported the multivariate adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) for the association between serum uric acid and risk of type 2 diabetes. We used both fix-effects and random-effects models to calculate the overall effect estimate. The heterogeneity across studies was tested by both Q statistic and I(2) statistic. Begg's funnel plot and Egger's regression test were used to assess the potential publication bias.<h4>Results</h4>We retrieved 7 eligible articles derived from 8 prospective cohort studies, involving a total of 32016 participants and 2930 incident type 2 diabetes. The combined RR of developing type 2 diabetes for the highest category of serum uric acid level compared with the lowest was 1.56(95% CI, 1.39-1.76). Dose-response analysis showed the risk of type 2 diabetes was increased by 6% per 1 mg/dl increment in serum uric acid level (RR 1.06, 95% CI: 1.04-1.07). The result from each subgroup showed a significant association between serum uric acid and risk of type 2 diabetes. In sensitive analysis, the combined RR was consistent every time omitting any one study. Little evidence of heterogeneity and publication bias was observed.<h4>Conclusions</h4>Our meta-analysis of prospective cohort studies provided strong evidence that high level of serum uric acid is independent of other established risk factors, especially metabolic syndrome components, for developing type 2 diabetes in middle-aged and older people.https://doi.org/10.1371/journal.pone.0056864 |
| spellingShingle | Qin Lv Xian-Fang Meng Fang-Fang He Shan Chen Hua Su Jing Xiong Pan Gao Xiu-Juan Tian Jian-She Liu Zhong-Hua Zhu Kai Huang Chun Zhang High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PLoS ONE |
| title | High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. |
| title_full | High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. |
| title_fullStr | High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. |
| title_full_unstemmed | High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. |
| title_short | High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. |
| title_sort | high serum uric acid and increased risk of type 2 diabetes a systemic review and meta analysis of prospective cohort studies |
| url | https://doi.org/10.1371/journal.pone.0056864 |
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