Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students
Background: Despite the widespread implementation of childhood vaccination programmes, hepatitis B virus (HBV) infection remains an ongoing occupational risk for healthcare students. In multi-ethnic and international university settings, differences in vaccination programmes and immune responses mus...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/7/771 |
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| author | Lorenzo Ippoliti Andrea Pizzo Agostino Paolino Luca Coppeta Giuseppe Bizzarro Cristiana Ferrari Andrea Mazza Claudia Salvi Ersilia Buonomo Fabian Cenko Andrea Magrini Antonio Pietroiusti |
| author_facet | Lorenzo Ippoliti Andrea Pizzo Agostino Paolino Luca Coppeta Giuseppe Bizzarro Cristiana Ferrari Andrea Mazza Claudia Salvi Ersilia Buonomo Fabian Cenko Andrea Magrini Antonio Pietroiusti |
| author_sort | Lorenzo Ippoliti |
| collection | DOAJ |
| description | Background: Despite the widespread implementation of childhood vaccination programmes, hepatitis B virus (HBV) infection remains an ongoing occupational risk for healthcare students. In multi-ethnic and international university settings, differences in vaccination programmes and immune responses must be considered. This retrospective study aimed to assess the prevalence of protective levels of anti-HBs among medical students at an international university in Rome, exploring associations with demographic and vaccination-related factors. Methods: Data were collected from routine occupational health surveillance conducted in 2023. Anti-HB titres were measured in 507 students, and information on age, sex, country of birth, age at vaccination, and time since the last dose was analysed. Results: Overall, 55.0% of students had antibody levels of at least 10 mIU/mL, indicating serological protection. Higher seroprotection rates were observed among students vaccinated in the first year of life compared to those vaccinated later. A significant decline in antibody titres was also associated with longer intervals since vaccination. Students born outside Europe tended to show lower levels of protection. Conclusions: These results emphasise the importance of screening future healthcare professionals and continuously monitoring antibody titres to help reduce HBV infections. |
| format | Article |
| id | doaj-art-cba654c634d3414f9fa0b14aebb3bae4 |
| institution | Matheson Library |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-cba654c634d3414f9fa0b14aebb3bae42025-07-25T13:38:30ZengMDPI AGVaccines2076-393X2025-07-0113777110.3390/vaccines13070771Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession StudentsLorenzo Ippoliti0Andrea Pizzo1Agostino Paolino2Luca Coppeta3Giuseppe Bizzarro4Cristiana Ferrari5Andrea Mazza6Claudia Salvi7Ersilia Buonomo8Fabian Cenko9Andrea Magrini10Antonio Pietroiusti11Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyFaculty of Medicine, University “Our Lady of Good Counsel”, 1000 Tirana, AlbaniaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyFaculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, ItalyBackground: Despite the widespread implementation of childhood vaccination programmes, hepatitis B virus (HBV) infection remains an ongoing occupational risk for healthcare students. In multi-ethnic and international university settings, differences in vaccination programmes and immune responses must be considered. This retrospective study aimed to assess the prevalence of protective levels of anti-HBs among medical students at an international university in Rome, exploring associations with demographic and vaccination-related factors. Methods: Data were collected from routine occupational health surveillance conducted in 2023. Anti-HB titres were measured in 507 students, and information on age, sex, country of birth, age at vaccination, and time since the last dose was analysed. Results: Overall, 55.0% of students had antibody levels of at least 10 mIU/mL, indicating serological protection. Higher seroprotection rates were observed among students vaccinated in the first year of life compared to those vaccinated later. A significant decline in antibody titres was also associated with longer intervals since vaccination. Students born outside Europe tended to show lower levels of protection. Conclusions: These results emphasise the importance of screening future healthcare professionals and continuously monitoring antibody titres to help reduce HBV infections.https://www.mdpi.com/2076-393X/13/7/771hepatitis Bvaccinationoccupational medicinehealthcare workers |
| spellingShingle | Lorenzo Ippoliti Andrea Pizzo Agostino Paolino Luca Coppeta Giuseppe Bizzarro Cristiana Ferrari Andrea Mazza Claudia Salvi Ersilia Buonomo Fabian Cenko Andrea Magrini Antonio Pietroiusti Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students Vaccines hepatitis B vaccination occupational medicine healthcare workers |
| title | Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students |
| title_full | Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students |
| title_fullStr | Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students |
| title_full_unstemmed | Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students |
| title_short | Evaluation of Anti-HB Levels in a Multi-Ethnic Cohort of Health Profession Students |
| title_sort | evaluation of anti hb levels in a multi ethnic cohort of health profession students |
| topic | hepatitis B vaccination occupational medicine healthcare workers |
| url | https://www.mdpi.com/2076-393X/13/7/771 |
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