STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES
The results of an experimental study of the effect of structure of substituting groups and pH value on the partition coefficients in biphasic systems of n-octanol and water for a number of 2,5-substituted 6-hydroxypyrimidine-4-(3H)-ones are presented.
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/426 |
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| _version_ | 1839586747205287936 |
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| author | A. E. Potapova A. A. Teslev |
| author_facet | A. E. Potapova A. A. Teslev |
| author_sort | A. E. Potapova |
| collection | DOAJ |
| description | The results of an experimental study of the effect of structure of substituting groups and pH value on the partition coefficients in biphasic systems of n-octanol and water for a number of 2,5-substituted 6-hydroxypyrimidine-4-(3H)-ones are presented. |
| format | Article |
| id | doaj-art-caa4709cfc67464cb10ca3669aee6ac9 |
| institution | Matheson Library |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-caa4709cfc67464cb10ca3669aee6ac92025-08-03T19:23:54ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102170174426STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVESA. E. Potapova0A. A. Teslev1Federal State Budgetary Educational Institution of Higher Education «Saint Petersburg Chemical-Pharmaceutical Academy» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Saint Petersburg Chemical-Pharmaceutical Academy» of the Ministry of Health of the Russian FederationThe results of an experimental study of the effect of structure of substituting groups and pH value on the partition coefficients in biphasic systems of n-octanol and water for a number of 2,5-substituted 6-hydroxypyrimidine-4-(3H)-ones are presented.https://www.pharmjournal.ru/jour/article/view/426pharmaceutical substance6-hydroxypyrimidine-4(3h)-onpartition coefficientabsorptionbiopharmacyheterocyclic compoundsphlipophilicity |
| spellingShingle | A. E. Potapova A. A. Teslev STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES Разработка и регистрация лекарственных средств pharmaceutical substance 6-hydroxypyrimidine-4(3h)-on partition coefficient absorption biopharmacy heterocyclic compounds ph lipophilicity |
| title | STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES |
| title_full | STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES |
| title_fullStr | STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES |
| title_full_unstemmed | STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES |
| title_short | STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES |
| title_sort | study of the effect of structure on octanol water distribution of 6 hydroxypyrimidine 4 i 3h i ones derivatives |
| topic | pharmaceutical substance 6-hydroxypyrimidine-4(3h)-on partition coefficient absorption biopharmacy heterocyclic compounds ph lipophilicity |
| url | https://www.pharmjournal.ru/jour/article/view/426 |
| work_keys_str_mv | AT aepotapova studyoftheeffectofstructureonoctanolwaterdistributionof6hydroxypyrimidine4i3hionesderivatives AT aateslev studyoftheeffectofstructureonoctanolwaterdistributionof6hydroxypyrimidine4i3hionesderivatives |