Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics
White spot syndrome virus (WSSV) has emerged as a significant threat to global shrimp aquaculture, causing economic losses because of its rapid spread and high mortality rates. This study aims to elucidate the genetic and evolutionary dynamics of WSSV through a comprehensive genome analysis. Utilizi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/14/6/653 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839654736496689152 |
|---|---|
| author | Zhouquan Li Guanghua Huang Jingyi Zhang Mingyou Li Zhizhi Liu Sihua Peng Rui Wang Dong Liu |
| author_facet | Zhouquan Li Guanghua Huang Jingyi Zhang Mingyou Li Zhizhi Liu Sihua Peng Rui Wang Dong Liu |
| author_sort | Zhouquan Li |
| collection | DOAJ |
| description | White spot syndrome virus (WSSV) has emerged as a significant threat to global shrimp aquaculture, causing economic losses because of its rapid spread and high mortality rates. This study aims to elucidate the genetic and evolutionary dynamics of WSSV through a comprehensive genome analysis. Utilizing 27 complete genome sequences sourced from public databases, this study investigates the genetic variability, potential recombination events, and evolutionary patterns of WSSV. Our results identified multiple genomic deletions, 14 novel single-nucleotide polymorphism sites, and variable number tandem repeats across different strains, underscoring the virus’s genetic diversity. A recombination event between freshwater and marine strains highlights a complex transmission pathway, potentially facilitated by aquaculture practices. A phylogenetic tree constructed using ancestral genes suggests that WSSV originated in Southeast Asia and subsequently globally spread, influenced by both natural and anthropogenic factors. Genomic shrinkage of the virus occurred in time series, while the host’s viral infection induced transposon transposition and insertion into the earlier virus genome to provide a basis for genomic shrinkage. Our research emphasizes the importance of advanced molecular characterization and evolutionary models of the virus in understanding the spread of viral pathogens in aquaculture environments. |
| format | Article |
| id | doaj-art-ca8beed858af4cbf9a1a3750b7f83324 |
| institution | Matheson Library |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-ca8beed858af4cbf9a1a3750b7f833242025-06-25T13:30:30ZengMDPI AGBiology2079-77372025-06-0114665310.3390/biology14060653Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon DynamicsZhouquan Li0Guanghua Huang1Jingyi Zhang2Mingyou Li3Zhizhi Liu4Sihua Peng5Rui Wang6Dong Liu7China (Guangxi)-ASEAN Key Laboratory of Comprehensive Exploitation and Utilization of Aquatic Germplasm Resources, Ministry of Agriculture and Rural Affairs, Guangxi Academy of Fishery Sciences, Nanning 530021, ChinaChina (Guangxi)-ASEAN Key Laboratory of Comprehensive Exploitation and Utilization of Aquatic Germplasm Resources, Ministry of Agriculture and Rural Affairs, Guangxi Academy of Fishery Sciences, Nanning 530021, ChinaShanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai Ocean University, Shanghai 201306, ChinaShanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai Ocean University, Shanghai 201306, ChinaShanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai Ocean University, Shanghai 201306, ChinaDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USAChina (Guangxi)-ASEAN Key Laboratory of Comprehensive Exploitation and Utilization of Aquatic Germplasm Resources, Ministry of Agriculture and Rural Affairs, Guangxi Academy of Fishery Sciences, Nanning 530021, ChinaShanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai Ocean University, Shanghai 201306, ChinaWhite spot syndrome virus (WSSV) has emerged as a significant threat to global shrimp aquaculture, causing economic losses because of its rapid spread and high mortality rates. This study aims to elucidate the genetic and evolutionary dynamics of WSSV through a comprehensive genome analysis. Utilizing 27 complete genome sequences sourced from public databases, this study investigates the genetic variability, potential recombination events, and evolutionary patterns of WSSV. Our results identified multiple genomic deletions, 14 novel single-nucleotide polymorphism sites, and variable number tandem repeats across different strains, underscoring the virus’s genetic diversity. A recombination event between freshwater and marine strains highlights a complex transmission pathway, potentially facilitated by aquaculture practices. A phylogenetic tree constructed using ancestral genes suggests that WSSV originated in Southeast Asia and subsequently globally spread, influenced by both natural and anthropogenic factors. Genomic shrinkage of the virus occurred in time series, while the host’s viral infection induced transposon transposition and insertion into the earlier virus genome to provide a basis for genomic shrinkage. Our research emphasizes the importance of advanced molecular characterization and evolutionary models of the virus in understanding the spread of viral pathogens in aquaculture environments.https://www.mdpi.com/2079-7737/14/6/653genomeevolutionrecombinationgenetic diversitytransposon |
| spellingShingle | Zhouquan Li Guanghua Huang Jingyi Zhang Mingyou Li Zhizhi Liu Sihua Peng Rui Wang Dong Liu Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics Biology genome evolution recombination genetic diversity transposon |
| title | Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics |
| title_full | Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics |
| title_fullStr | Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics |
| title_full_unstemmed | Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics |
| title_short | Genomic Evolution of White Spot Syndrome Virus in Shrimp: Insights from Transposon Dynamics |
| title_sort | genomic evolution of white spot syndrome virus in shrimp insights from transposon dynamics |
| topic | genome evolution recombination genetic diversity transposon |
| url | https://www.mdpi.com/2079-7737/14/6/653 |
| work_keys_str_mv | AT zhouquanli genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT guanghuahuang genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT jingyizhang genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT mingyouli genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT zhizhiliu genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT sihuapeng genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT ruiwang genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics AT dongliu genomicevolutionofwhitespotsyndromevirusinshrimpinsightsfromtransposondynamics |