Ablation of the Evolutionarily Acquired Functions of the <i>Atp1b4</i> Gene Increases Metabolic Capacity and Reduces Obesity

Ablation of the Evolutionarily Acquired Functions of the <i>Atp1b4</i> Gene Increases Metabolic Capacity and Reduces Obesity

In placental mammals, the co-option of vertebrate orthologous <i>ATP1B4</i> genes has profoundly altered the properties of the encoded BetaM proteins, which function as bona fide β-subunits of Na,K-ATPases in lower vertebrates. Eutherian BetaM acquired an extended Glu-rich N-terminal dom...

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Bibliographic Details
Main Authors: Nikolai N. Modyanov, Lucia Russo, Sumona Ghosh Lester, Tamara R. Castañeda, Himangi G. Marathe, Larisa V. Fedorova, Raymond E. Bourey, Sonia M. Najjar, Ivana L. de la Serna
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Life
Subjects:
<i>ATP1B4</i>
gene co-option
placental mammal evolution
muscle
metabolism
obesity
Online Access:https://www.mdpi.com/2075-1729/15/7/1103
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