Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for Transdermal Delivery

QR Code

Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for Transdermal Delivery

Abstract Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine nanopar...

Full description

Saved in:

Bibliographic Details
Main Authors:	Abulfadhel jaber neamah AL-shaibani, Mowafaq M. Ghareeb
Format:	Article
Language:	English
Published:	College of Pharmacy University of Baghdad 2025-06-01
Series:	Iraqi Journal of Pharmaceutical Sciences
Subjects:	Olanzapine, Nanoparticle, Solubility, Polymers, Microneedle.
Online Access:	https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3113
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

MICRONEEDLES AS A WAY TO INCREASE THE TRANSDERMAL INSULIN DELIVERY
by: E. G. Kuznetsova, et al.
Published: (2017-01-01)

Design of scalable manufacturing process for the production of biodegradable polymeric microneedles for protein transdermal drug delivery
by: M. S. Zolotareva, et al.
Published: (2024-09-01)

Tunable Intranasal Polymersome Nanocarriers Triggered Olanzapine Brain Delivery and Improved In Vivo Antipsychotic Activity
by: Ahmed A. Katamesh, et al.
Published: (2025-06-01)

Enhanced transdermal delivery of lidocaine cream via ultrasound and microneedle rollers
by: Jiaxiao Sun, et al.
Published: (2025-07-01)

Functionalized Polymeric Microneedles for Transdermal Delivery of Ovalbumin Protein Antigen
by: Yi Liu, et al.
Published: (2025-06-01)

Effect of olanzapine on laying performance of Americal king pigeons and approach to the mechanisms
by: ZHAO Wen-jing, et al.
Published: (2011-01-01)

Progressive microneedles for targeting and intelligent drug delivery
by: Jiaqi Li, et al.
Published: (2025-06-01)

Negative Impact of Olanzapine on ICU Delirium Resolution: An Emulated Clinical Trial
by: Ajna Hamidovic, et al.
Published: (2025-07-01)

Efficacy of Dissolvable Microneedle Patches with Skincare Actives in Acne Management: A Monocentric Clinical Trial
by: Muhammet Avcil, et al.
Published: (2025-05-01)

Efficacy and safety of olanzapine for treatment of patients with bipolar depression: Chinese subpopulation analysis of a double-blind, randomized, placebo-controlled study
by: Wang G, et al.
Published: (2016-08-01)

Comparing the Effect of Adding Olanzapine Versus Perphenazine on Maintenance Treatment of Bipolar Type 1
by: Ahmad Fakhri, et al.
Published: (2012-03-01)

Signal mining and risk analysis of olanzapine adverse events in the FAERS database
by: Aiguo Dong, et al.
Published: (2025-07-01)

Bioequivalence study of tablet forms of risperidone, olanzapine and quetiapine in healthy volunteers
by: V. V. Pisarev, et al.
Published: (2013-04-01)

Electrical Microneedles for Wound Treatment
by: Yu Wang, et al.
Published: (2025-06-01)

Clinical outcomes with olanzapine long-acting injection: impact of the 3-hour observation period on patient satisfaction and well-being
by: Anand E, et al.
Published: (2016-10-01)

Case Report: I want more olanzapine: pharmacogenetic insights into a patient's preference for high-dose olanzapine
by: Liam Korošec Hudnik, et al.
Published: (2025-07-01)

Process of Fabricating Hyaluronic Acid-Based Milli-to-Microneedles Using the Bi-Directional Drawing Method
by: Joon-Koo Kang, et al.
Published: (2025-05-01)

Chemical and Toxicological Diagnosis of Acute Poisoning with Clozapine, Olanzapine, Quetiapine and Risperidone
by: M. V. Belova, et al.
Published: (2020-10-01)

Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors
by: Akmal H. Sabri, et al.
Published: (2025-12-01)

Advances in clinical applications of microneedle
by: Kequan Chen, et al.
Published: (2025-06-01)

Transdermal drug delivery system: A comprehensive review of innovative strategies, applications, and regulatory perspectives
by: Andrea Crasta, et al.
Published: (2025-07-01)

Microneedles at the Forefront of Next Generation Theranostics
by: Chan Wang, et al.
Published: (2025-06-01)

Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview
by: Guillermo Conejo‐Cuevas, et al.
Published: (2025-07-01)

From mechanism to applications: Advanced microneedles for clinical medicine
by: Yuqing Yang, et al.
Published: (2025-09-01)

Recent Progress on the Application of Microneedles for In Situ Sampling in Surface-Enhanced Raman Scattering Detection
by: Weiqing Yang, et al.
Published: (2025-06-01)

Self-propelled gas nanomotor-integrated microneedles for melanoma therapy: Dual-action in situ eradication and metastatic suppression
by: Chungchi Lee, et al.
Published: (2025-10-01)

Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy
by: Ting Wen, et al.
Published: (2025-07-01)

3D-Printed microneedle assays for point-of-care applications
by: Haoyang Yan, et al.
Published: (2025-06-01)

Comparative Efficacy of Tranexamic Acid and Vitamin C with Microneedling: A Split-Face Study in Melasma Management
by: Sabiha Quazi, et al.
Published: (2025-06-01)

Critical Role of Surface Properties in Passive Interstitial Fluid Extraction Using Polymeric Hollow Microneedles for Wearable Diagnostics
by: Ipek Atay, et al.
Published: (2025-07-01)

Designing Multifunctional Microneedles in Biomedical Engineering: Materials, Methods, and Applications
by: Liu L, et al.
Published: (2025-07-01)

Restoration of tendon repair microenvironment by grapefruit exosome-loaded microneedle system for tendinopathy therapy
by: Yuan Zhang, et al.
Published: (2025-07-01)

Novel stereo DIC characterisation of microneedle and hypodermic needle insertion
by: Megan McNamee, et al.
Published: (2025-06-01)

Dual nanozymes-loaded core-shell microneedle patches with antibacterial and NETs-degradation bifunctional properties for periodontitis treatment
by: Yue Shan, et al.
Published: (2025-11-01)

Multifunctional MOF microneedle patch with adsorbed exosomes for enhanced diabetic wound healing
by: Jieyu Xiang, et al.
Published: (2025-08-01)

Glucose responsive microneedle patch using a reversible and an irreversible crosslinking agents
by: Mitra Teymoori, et al.
Published: (2025-09-01)

Dissolving Microneedle Transdermal Patch Loaded with Nanoliposomes of Enicostemma littorale for the Management of Type II Diabetes
by: Mohammed H. Alqarni, et al.
Published: (2025-06-01)

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis
by: Li Lu, et al.
Published: (2025-07-01)

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing
by: Youjun Ding, et al.
Published: (2025-07-01)

3D-Printed PLA Hollow Microneedles Loaded with Chitosan Nanoparticles for Colorimetric Glucose Detection in Sweat Using Machine Learning
by: Anastasia Skonta, et al.
Published: (2025-07-01)