PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS
Background. The change in the spectrum of short-chain fatty acids (SCFA) is known to be one of the links of carcinogenesis.The aim of study was to assess the correlation between the levels of cell proliferation, apoptosis, cell cycle kinetics and the spectrum of short-chain fatty acids in cervical d...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2018-03-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/668 |
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| _version_ | 1839579565517701120 |
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| author | E. V. Kayukova T. E. Belokrinitskaya T. V. Kayukova B. S. Khyshiktuev |
| author_facet | E. V. Kayukova T. E. Belokrinitskaya T. V. Kayukova B. S. Khyshiktuev |
| author_sort | E. V. Kayukova |
| collection | DOAJ |
| description | Background. The change in the spectrum of short-chain fatty acids (SCFA) is known to be one of the links of carcinogenesis.The aim of study was to assess the correlation between the levels of cell proliferation, apoptosis, cell cycle kinetics and the spectrum of short-chain fatty acids in cervical dysplasia and cancer cells.Methods. To analyze the association between the variables, the Spearman’s rank correlation was used.Results. The SCFA is likely to have anti-proliferative, pro-apoptotic, and modulatory effects on the cell cycle phase.Conclusion. Correlations between the level of SCFA and parameters of apoptosis, necrosis, and cell cycle phases indicates their pathogenetic participation in the cervical carcinogenesis. |
| format | Article |
| id | doaj-art-c95f8fa8ca4d45c1b15cd1e83e4e546f |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2018-03-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-c95f8fa8ca4d45c1b15cd1e83e4e546f2025-08-04T10:33:38ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-03-01171323710.21294/1814-4861-2018-17-1-32-37513PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESISE. V. Kayukova0T. E. Belokrinitskaya1T. V. Kayukova2B. S. Khyshiktuev3Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyMedicom LLCBackground. The change in the spectrum of short-chain fatty acids (SCFA) is known to be one of the links of carcinogenesis.The aim of study was to assess the correlation between the levels of cell proliferation, apoptosis, cell cycle kinetics and the spectrum of short-chain fatty acids in cervical dysplasia and cancer cells.Methods. To analyze the association between the variables, the Spearman’s rank correlation was used.Results. The SCFA is likely to have anti-proliferative, pro-apoptotic, and modulatory effects on the cell cycle phase.Conclusion. Correlations between the level of SCFA and parameters of apoptosis, necrosis, and cell cycle phases indicates their pathogenetic participation in the cervical carcinogenesis.https://www.siboncoj.ru/jour/article/view/668cervical cancershort chain fatty acidsapoptosisproliferationcancerogenesis |
| spellingShingle | E. V. Kayukova T. E. Belokrinitskaya T. V. Kayukova B. S. Khyshiktuev PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS Сибирский онкологический журнал cervical cancer short chain fatty acids apoptosis proliferation cancerogenesis |
| title | PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS |
| title_full | PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS |
| title_fullStr | PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS |
| title_full_unstemmed | PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS |
| title_short | PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS |
| title_sort | pathogenic and correlative relationship between the level of short chain fatty acids and the intensity of biological process in cervical cancer cells during cancerogenesis |
| topic | cervical cancer short chain fatty acids apoptosis proliferation cancerogenesis |
| url | https://www.siboncoj.ru/jour/article/view/668 |
| work_keys_str_mv | AT evkayukova pathogenicandcorrelativerelationshipbetweenthelevelofshortchainfattyacidsandtheintensityofbiologicalprocessincervicalcancercellsduringcancerogenesis AT tebelokrinitskaya pathogenicandcorrelativerelationshipbetweenthelevelofshortchainfattyacidsandtheintensityofbiologicalprocessincervicalcancercellsduringcancerogenesis AT tvkayukova pathogenicandcorrelativerelationshipbetweenthelevelofshortchainfattyacidsandtheintensityofbiologicalprocessincervicalcancercellsduringcancerogenesis AT bskhyshiktuev pathogenicandcorrelativerelationshipbetweenthelevelofshortchainfattyacidsandtheintensityofbiologicalprocessincervicalcancercellsduringcancerogenesis |