Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test
Background. Cyclo-L-prolylglycine (CPG) was designed and synthesized at the V.V. Zakusov as a topological analogue of the classical nootrop piracetam and was further identified as an endogenous compound. Previously, the nootropic effect of CPG was revealed in a model of retrograde amnesia in rats indu...
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2023-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/381 |
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| author | O. N. Vorontsova A. G. Alyaeva K. N. Koliasnikova E. A. Valdman P. Yu. Povarnina |
| author_facet | O. N. Vorontsova A. G. Alyaeva K. N. Koliasnikova E. A. Valdman P. Yu. Povarnina |
| author_sort | O. N. Vorontsova |
| collection | DOAJ |
| description | Background. Cyclo-L-prolylglycine (CPG) was designed and synthesized at the V.V. Zakusov as a topological analogue of the classical nootrop piracetam and was further identified as an endogenous compound. Previously, the nootropic effect of CPG was revealed in a model of retrograde amnesia in rats induced by electroconvulsive shock in the passive avoidance test (PAT).Objective. The aim of the present study was to investigate the nootropic effect of CPG under more physiological conditions in the absence of strong stressors.Methods. Amnesia in rats was modeled by intraperitoneal (ip) administration of scopolamine at a dose of 2 mg/kg. CPG was administered ip at doses of 0.1 and 1.0 mg/kg 15 minutes after scopolamine. Short- and long-term memory were recorded in the novel object recognition test.Results. It was found that scopolamine disrupted only the long-term memory of rats. CPG at a dose of 0.1 mg/ kg almost completely counteracted this impairment. CPG by itself had no effect on memory at both doses studied.Conclusion. Thus, CPG exhibits nootropic activity not only in the aversive conditions of the PAT and electroconvulsive shock-induced amnesia, but also in the neutral situation in the novel object recognition test, when the amnesia was caused by the administration of scopolamine. |
| format | Article |
| id | doaj-art-c9034e386a724e5da60cea30e5df46cb |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | LLC “Publisher OKI” |
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| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-c9034e386a724e5da60cea30e5df46cb2025-08-03T13:00:47ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302023-11-0103505510.37489/2587-7836-2023-3-50-55344Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition testO. N. Vorontsova0A. G. Alyaeva1K. N. Koliasnikova2E. A. Valdman3P. Yu. Povarnina4FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”FSBI “Research Zakusov Institue of Pharmacology”Background. Cyclo-L-prolylglycine (CPG) was designed and synthesized at the V.V. Zakusov as a topological analogue of the classical nootrop piracetam and was further identified as an endogenous compound. Previously, the nootropic effect of CPG was revealed in a model of retrograde amnesia in rats induced by electroconvulsive shock in the passive avoidance test (PAT).Objective. The aim of the present study was to investigate the nootropic effect of CPG under more physiological conditions in the absence of strong stressors.Methods. Amnesia in rats was modeled by intraperitoneal (ip) administration of scopolamine at a dose of 2 mg/kg. CPG was administered ip at doses of 0.1 and 1.0 mg/kg 15 minutes after scopolamine. Short- and long-term memory were recorded in the novel object recognition test.Results. It was found that scopolamine disrupted only the long-term memory of rats. CPG at a dose of 0.1 mg/ kg almost completely counteracted this impairment. CPG by itself had no effect on memory at both doses studied.Conclusion. Thus, CPG exhibits nootropic activity not only in the aversive conditions of the PAT and electroconvulsive shock-induced amnesia, but also in the neutral situation in the novel object recognition test, when the amnesia was caused by the administration of scopolamine.https://www.pharmacokinetica.ru/jour/article/view/381cycloprolylglycinenootropic activityscopolamine amnesianovel object recognition test |
| spellingShingle | O. N. Vorontsova A. G. Alyaeva K. N. Koliasnikova E. A. Valdman P. Yu. Povarnina Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test Фармакокинетика и Фармакодинамика cycloprolylglycine nootropic activity scopolamine amnesia novel object recognition test |
| title | Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test |
| title_full | Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test |
| title_fullStr | Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test |
| title_full_unstemmed | Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test |
| title_short | Neuropeptide cyclo-L-prolylglycine counteracts scopolamine-induced long-term memory impairment in rats in the novel object recognition test |
| title_sort | neuropeptide cyclo l prolylglycine counteracts scopolamine induced long term memory impairment in rats in the novel object recognition test |
| topic | cycloprolylglycine nootropic activity scopolamine amnesia novel object recognition test |
| url | https://www.pharmacokinetica.ru/jour/article/view/381 |
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