Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review
Zhiying Wang,1,* Zhixian Zhong,2,* Wenxiao Yang,1 Yun Li,3 Ke Zhang,3 Yabin Gong,1 Lijing Jiao,1,4 Ling Xu1,4 1Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 20043...
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Dove Medical Press
2025-06-01
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| author | Wang Z Zhong Z Yang W Li Y Zhang K Gong Y Jiao L Xu L |
| author_facet | Wang Z Zhong Z Yang W Li Y Zhang K Gong Y Jiao L Xu L |
| author_sort | Wang Z |
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| description | Zhiying Wang,1,* Zhixian Zhong,2,* Wenxiao Yang,1 Yun Li,3 Ke Zhang,3 Yabin Gong,1 Lijing Jiao,1,4 Ling Xu1,4 1Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People’s Republic of China; 2Department of Oncology, East Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 3Department of Oncology, Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, People’s Republic of China; 4Institute of Translational Cancer Research for Integrated Chinese and Western Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Xu, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Email doctor200004@163.com Lijing Jiao, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Email jlj969@163.comAbstract: Non‑small cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer cases. Epidermal growth factor receptor (EGFR) with L858R/T790M mutations are commonly found in clinical practice and usually results in resistance to first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Osimertinib is currently the first-line treatment choice for patients with EGFR L858R/T790M mutations, however, as to other EGFR-TKIs, resistance inevitably occurs. There is substantial evidence supporting the efficacy of traditional Chinese medicine (TCM) in the prevention and treatment of non-small cell lung cancer (NSCLC). The mechanisms underlying these effects involve the modulation of key cellular processes, including proliferation, apoptosis, cell cycle regulation, migration, invasion, autophagy, and epithelial–mesenchymal transition. TCM achieves these effects by regulating multiple signaling pathways and mechanisms, while also exhibiting synergistic interactions with EGFR tyrosine kinase inhibitors (TKIs). This review highlights the mechanisms through which TCM influences NSCLC patients harboring EGFR mutations, offering a promising therapeutic strategy for those with EGFR-TKI resistance.Keywords: traditional Chinese medicine, NSCLC, EGFR, L858R/T790M mutations |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-c8b4fe53c64e4fc2913f3fa9e90de54d2025-06-25T21:33:44ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-06-01Volume 19Issue 151695191104016Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A ReviewWang ZZhong Z0Yang WLi Y1Zhang K2Gong Y3Jiao L4Xu LEast Hospital Affiliated To Tongji UniversityDepartment of OncologyMinimally Invasive Treatment CenterDepartment of OncologyDepartment of OncologyZhiying Wang,1,* Zhixian Zhong,2,* Wenxiao Yang,1 Yun Li,3 Ke Zhang,3 Yabin Gong,1 Lijing Jiao,1,4 Ling Xu1,4 1Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People’s Republic of China; 2Department of Oncology, East Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 3Department of Oncology, Shanghai Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, People’s Republic of China; 4Institute of Translational Cancer Research for Integrated Chinese and Western Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Xu, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Email doctor200004@163.com Lijing Jiao, Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine, 110 Ganhe Road, Shanghai, 200437, People’s Republic of China, Email jlj969@163.comAbstract: Non‑small cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer cases. Epidermal growth factor receptor (EGFR) with L858R/T790M mutations are commonly found in clinical practice and usually results in resistance to first- and second-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Osimertinib is currently the first-line treatment choice for patients with EGFR L858R/T790M mutations, however, as to other EGFR-TKIs, resistance inevitably occurs. There is substantial evidence supporting the efficacy of traditional Chinese medicine (TCM) in the prevention and treatment of non-small cell lung cancer (NSCLC). The mechanisms underlying these effects involve the modulation of key cellular processes, including proliferation, apoptosis, cell cycle regulation, migration, invasion, autophagy, and epithelial–mesenchymal transition. TCM achieves these effects by regulating multiple signaling pathways and mechanisms, while also exhibiting synergistic interactions with EGFR tyrosine kinase inhibitors (TKIs). This review highlights the mechanisms through which TCM influences NSCLC patients harboring EGFR mutations, offering a promising therapeutic strategy for those with EGFR-TKI resistance.Keywords: traditional Chinese medicine, NSCLC, EGFR, L858R/T790M mutationshttps://www.dovepress.com/traditional-chinese-medicines-as-anticancer-agents-for-non-small-cell--peer-reviewed-fulltext-article-DDDTTraditional Chinese MedicineNSCLCEGFRL858R/T790M mutations |
| spellingShingle | Wang Z Zhong Z Yang W Li Y Zhang K Gong Y Jiao L Xu L Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review Drug Design, Development and Therapy Traditional Chinese Medicine NSCLC EGFR L858R/T790M mutations |
| title | Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review |
| title_full | Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review |
| title_fullStr | Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review |
| title_full_unstemmed | Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review |
| title_short | Traditional Chinese Medicines as Anticancer Agents for Non-Small Cell Lung Cancer with EGFR Mutations: A Review |
| title_sort | traditional chinese medicines as anticancer agents for non small cell lung cancer with egfr mutations a review |
| topic | Traditional Chinese Medicine NSCLC EGFR L858R/T790M mutations |
| url | https://www.dovepress.com/traditional-chinese-medicines-as-anticancer-agents-for-non-small-cell--peer-reviewed-fulltext-article-DDDT |
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