Endothelial cell proliferation and extracellular matrix-related pathways regulate pulmonary arterial hypertension in rat models

Endothelial cell proliferation and extracellular matrix-related pathways regulate pulmonary arterial hypertension in rat models

Objective To identify mechanisms regulating disease progression in rat models of pulmonary arterial hypertension (PAH). Methods Rat PAH models were established using subcutaneous monocrotaline (MCT) injection and the SU5416/hypoxia (SU/Hx) method. Transcriptomic sequencing of lung tissues was perfor...

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Bibliographic Details
Main Author: LU Xiaoxuan, GUO Lina, ZHANG Hong, SONG Wanlu, HU Yufei, YANG Peiran
Format: Article
Language:Chinese
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-06-01
Series:Jichu yixue yu linchuang
Subjects:
pulmonary artery hypertension (pah)|animal model|endothelial cell|extracellular matrix (ecm)
Online Access:https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-6-770.pdf
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