Selection of aptamers against the Jagged-1 protein
The breast cancer is one of the biggest public health problems in the world, being the main female type of cancer that affects the population. The Jagged-1 protein plays an important role in the biology and development of cancer, influencing angiogenesis, growth of neoplastic cells, tumor stem cells...
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| Format: | Article |
| Language: | English |
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Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)
2022-12-01
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| Series: | Brazilian Journal of Radiation Sciences |
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| Online Access: | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1933 |
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| _version_ | 1839628123317993472 |
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| author | Fábio Fernando Alves da Silva Emerson Soares Bernardes |
| author_facet | Fábio Fernando Alves da Silva Emerson Soares Bernardes |
| author_sort | Fábio Fernando Alves da Silva |
| collection | DOAJ |
| description | The breast cancer is one of the biggest public health problems in the world, being the main female type of cancer that affects the population. The Jagged-1 protein plays an important role in the biology and development of cancer, influencing angiogenesis, growth of neoplastic cells, tumor stem cells, epithelial mesenchymal transition, metastatic processes and resistance to therapies in various types of cancer. In this project, our aim was to select an aptamer for JAG1 ligand using an aptamer library, that could be used as a radiopharmaceutical for PET / SPECT / CT diagnosis of tumors that express JAG1. Our work showed that MDA-MB-231-JAG1 cells overexpress more mRNA and JAG1 protein than control cells (MDA-MB-231-Control). We also selected aptamers with high affinity for MDA-MB-231-JAG1 cells that could be a useful tool for the development of new radiopharmaceuticals for the diagnosis and treatment of tumors that overexpress JAG1. |
| format | Article |
| id | doaj-art-c86ab1b347da48b9b7c7d2c9ab438fdb |
| institution | Matheson Library |
| issn | 2319-0612 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Brazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR) |
| record_format | Article |
| series | Brazilian Journal of Radiation Sciences |
| spelling | doaj-art-c86ab1b347da48b9b7c7d2c9ab438fdb2025-07-16T00:44:54ZengBrazilian Radiation Protection Society (Sociedade Brasileira de Proteção Radiológica, SBPR)Brazilian Journal of Radiation Sciences2319-06122022-12-01103B (Suppl.)10.15392/2319-0612.2022.19331551Selection of aptamers against the Jagged-1 proteinFábio Fernando Alves da Silva0Emerson Soares BernardesNuclear and Energy Research InstituteThe breast cancer is one of the biggest public health problems in the world, being the main female type of cancer that affects the population. The Jagged-1 protein plays an important role in the biology and development of cancer, influencing angiogenesis, growth of neoplastic cells, tumor stem cells, epithelial mesenchymal transition, metastatic processes and resistance to therapies in various types of cancer. In this project, our aim was to select an aptamer for JAG1 ligand using an aptamer library, that could be used as a radiopharmaceutical for PET / SPECT / CT diagnosis of tumors that express JAG1. Our work showed that MDA-MB-231-JAG1 cells overexpress more mRNA and JAG1 protein than control cells (MDA-MB-231-Control). We also selected aptamers with high affinity for MDA-MB-231-JAG1 cells that could be a useful tool for the development of new radiopharmaceuticals for the diagnosis and treatment of tumors that overexpress JAG1.https://bjrs.org.br/revista/index.php/REVISTA/article/view/1933breast cancer, aptamer, jagged-1 |
| spellingShingle | Fábio Fernando Alves da Silva Emerson Soares Bernardes Selection of aptamers against the Jagged-1 protein Brazilian Journal of Radiation Sciences breast cancer, aptamer, jagged-1 |
| title | Selection of aptamers against the Jagged-1 protein |
| title_full | Selection of aptamers against the Jagged-1 protein |
| title_fullStr | Selection of aptamers against the Jagged-1 protein |
| title_full_unstemmed | Selection of aptamers against the Jagged-1 protein |
| title_short | Selection of aptamers against the Jagged-1 protein |
| title_sort | selection of aptamers against the jagged 1 protein |
| topic | breast cancer, aptamer, jagged-1 |
| url | https://bjrs.org.br/revista/index.php/REVISTA/article/view/1933 |
| work_keys_str_mv | AT fabiofernandoalvesdasilva selectionofaptamersagainstthejagged1protein AT emersonsoaresbernardes selectionofaptamersagainstthejagged1protein |