Photodynamic therapy with photosensitizer photolon for oral leukoplakia
The objective – to assess tolerability, safety and immediate results of treatment of patients with oral leukoplakia using photodynamic therapy (PDT) with a photosensitizer photolon. The study included 40 patients (7 men, 33 women) with morphologically verified leukoplakia of the oral mucosa. The ave...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2016-07-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/88 |
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| author | Yu. P. Istomin T. P. Artemyeva D. A. Tzerkovsky |
| author_facet | Yu. P. Istomin T. P. Artemyeva D. A. Tzerkovsky |
| author_sort | Yu. P. Istomin |
| collection | DOAJ |
| description | The objective – to assess tolerability, safety and immediate results of treatment of patients with oral leukoplakia using photodynamic therapy (PDT) with a photosensitizer photolon. The study included 40 patients (7 men, 33 women) with morphologically verified leukoplakia of the oral mucosa. The average age – 55±14 years. Number of treated foci – 109 (1 to 8). Photolon was administered intravenously at doses of 1.7-2.5 mg/kg. Photoirradiation («UPL PDT», Belarus, λ = 660±5 nm) was performed 2.5-3 h after administration: light exposure dose varied from 25 to 100 J/cm2, power density of 0.07 to 0.32 W/cm2, the duration of one field photoirradiation – from 2 to 13.5 min and according to its linear dimensions. The effectiveness of treatment was assessed 1-2 months after PDT by clinical data. Complete regression of foci recorded in 95% of cases (n=38), partial – in 5% (n=2).The follow-up period varied from 1 to 30 months. Full-epithelialization of the wound defect occurred within the period of 3-6 weeks after treatment. Photodynamic therapy may be recommended for patients with circumscribed or widespread oral leukoplakia as a simple, well-tolerated and effective option. Keywords: photodynamic therapy, photolon, oral leukoplakia. |
| format | Article |
| id | doaj-art-c81a3265ad8f44acb5fda0de81aa5a93 |
| institution | Matheson Library |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2016-07-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-c81a3265ad8f44acb5fda0de81aa5a932025-08-04T13:14:23ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322016-07-0152132010.24931/2413-9432-2016-5-2-13-2085Photodynamic therapy with photosensitizer photolon for oral leukoplakiaYu. P. Istomin0T. P. Artemyeva1D. A. Tzerkovsky2N.N. Alexandrov National Cancer Centre of BelarusN.N. Alexandrov National Cancer Centre of BelarusN.N. Alexandrov National Cancer Centre of BelarusThe objective – to assess tolerability, safety and immediate results of treatment of patients with oral leukoplakia using photodynamic therapy (PDT) with a photosensitizer photolon. The study included 40 patients (7 men, 33 women) with morphologically verified leukoplakia of the oral mucosa. The average age – 55±14 years. Number of treated foci – 109 (1 to 8). Photolon was administered intravenously at doses of 1.7-2.5 mg/kg. Photoirradiation («UPL PDT», Belarus, λ = 660±5 nm) was performed 2.5-3 h after administration: light exposure dose varied from 25 to 100 J/cm2, power density of 0.07 to 0.32 W/cm2, the duration of one field photoirradiation – from 2 to 13.5 min and according to its linear dimensions. The effectiveness of treatment was assessed 1-2 months after PDT by clinical data. Complete regression of foci recorded in 95% of cases (n=38), partial – in 5% (n=2).The follow-up period varied from 1 to 30 months. Full-epithelialization of the wound defect occurred within the period of 3-6 weeks after treatment. Photodynamic therapy may be recommended for patients with circumscribed or widespread oral leukoplakia as a simple, well-tolerated and effective option. Keywords: photodynamic therapy, photolon, oral leukoplakia.https://www.pdt-journal.com/jour/article/view/88istomin yu.p.artemyeva t.p.tzerkovsky d.a. photodynamic therapy with photosensitizer photolon for oral leukoplakiabiomedical photonics2016t. 5no. 2pp. 13–20 (in russian) |
| spellingShingle | Yu. P. Istomin T. P. Artemyeva D. A. Tzerkovsky Photodynamic therapy with photosensitizer photolon for oral leukoplakia Biomedical Photonics istomin yu.p. artemyeva t.p. tzerkovsky d.a. photodynamic therapy with photosensitizer photolon for oral leukoplakia biomedical photonics 2016 t. 5 no. 2 pp. 13–20 (in russian) |
| title | Photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| title_full | Photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| title_fullStr | Photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| title_full_unstemmed | Photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| title_short | Photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| title_sort | photodynamic therapy with photosensitizer photolon for oral leukoplakia |
| topic | istomin yu.p. artemyeva t.p. tzerkovsky d.a. photodynamic therapy with photosensitizer photolon for oral leukoplakia biomedical photonics 2016 t. 5 no. 2 pp. 13–20 (in russian) |
| url | https://www.pdt-journal.com/jour/article/view/88 |
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