Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration
Mineral nanoparticles and osteoinductive biomaterials are essential in advancing bone regeneration by addressing skeletal conditions and injuries that compromise structural integrity and functionality. These biomaterials stimulate the differentiation of precursor cells into osteoblasts, creating bio...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-03-01
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| Series: | Exploration of BioMat-X |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A101332/101332.pdf |
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| author | Cho-E Choi Arghya Paul |
| author_facet | Cho-E Choi Arghya Paul |
| author_sort | Cho-E Choi |
| collection | DOAJ |
| description | Mineral nanoparticles and osteoinductive biomaterials are essential in advancing bone regeneration by addressing skeletal conditions and injuries that compromise structural integrity and functionality. These biomaterials stimulate the differentiation of precursor cells into osteoblasts, creating biocompatible environments conducive to bone tissue regeneration. Among the most promising innovations, mineral-based nanoparticles and nanocomposite hydrogels have emerged as effective strategies for enhancing osteoinductive potential. This review explores the diverse types of osteoinductive biomaterials, including natural sources, synthetic compounds, and hybrid designs that incorporate mineralized nanoparticles. Emphasis is placed on polymeric hydrogels as delivery platforms for these materials, highlighting their dual role as structural supports and bioactive agents that promote osteogenesis. Challenges such as immune rejection, biodegradability, mechanical stability, and short in vivo residence time are critically discussed, alongside their impact on clinical translation. By presenting a comprehensive analysis of mechanisms, applications, and limitations, this review identifies opportunities for integrating osteoinductive biomaterials with emerging fields like immunology and biomechanics. Ultimately, this work aims to provide actionable insights and advance the development of novel, clinically relevant solutions that improve patient outcomes and address the growing global need for effective bone repair and regeneration. |
| format | Article |
| id | doaj-art-c7765f7c48da4f2e9f3fd71514b23cae |
| institution | Matheson Library |
| issn | 2996-9476 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of BioMat-X |
| spelling | doaj-art-c7765f7c48da4f2e9f3fd71514b23cae2025-07-15T01:58:29ZengOpen Exploration Publishing Inc.Exploration of BioMat-X2996-94762025-03-0121708210.37349/ebmx.2025.101332Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regenerationCho-E Choi0https://orcid.org/0009-0005-9487-8985Arghya Paul1https://orcid.org/0000-0003-4788-0378Department of Chemical and Biochemical Engineering, School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, CanadaDepartment of Chemical and Biochemical Engineering, School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada; Department of Chemistry, The Centre for Advanced Materials and Biomaterials Research, The University of Western Ontario, London, ON N6A 5B9, CanadaMineral nanoparticles and osteoinductive biomaterials are essential in advancing bone regeneration by addressing skeletal conditions and injuries that compromise structural integrity and functionality. These biomaterials stimulate the differentiation of precursor cells into osteoblasts, creating biocompatible environments conducive to bone tissue regeneration. Among the most promising innovations, mineral-based nanoparticles and nanocomposite hydrogels have emerged as effective strategies for enhancing osteoinductive potential. This review explores the diverse types of osteoinductive biomaterials, including natural sources, synthetic compounds, and hybrid designs that incorporate mineralized nanoparticles. Emphasis is placed on polymeric hydrogels as delivery platforms for these materials, highlighting their dual role as structural supports and bioactive agents that promote osteogenesis. Challenges such as immune rejection, biodegradability, mechanical stability, and short in vivo residence time are critically discussed, alongside their impact on clinical translation. By presenting a comprehensive analysis of mechanisms, applications, and limitations, this review identifies opportunities for integrating osteoinductive biomaterials with emerging fields like immunology and biomechanics. Ultimately, this work aims to provide actionable insights and advance the development of novel, clinically relevant solutions that improve patient outcomes and address the growing global need for effective bone repair and regeneration.https://www.explorationpub.com/uploads/Article/A101332/101332.pdfosteoinductive biomaterialshydrogelbone tissue regeneration |
| spellingShingle | Cho-E Choi Arghya Paul Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration Exploration of BioMat-X osteoinductive biomaterials hydrogel bone tissue regeneration |
| title | Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| title_full | Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| title_fullStr | Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| title_full_unstemmed | Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| title_short | Mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| title_sort | mineral nanoparticles and nanocomposite hydrogels with osteoinductive properties for bone regeneration |
| topic | osteoinductive biomaterials hydrogel bone tissue regeneration |
| url | https://www.explorationpub.com/uploads/Article/A101332/101332.pdf |
| work_keys_str_mv | AT choechoi mineralnanoparticlesandnanocompositehydrogelswithosteoinductivepropertiesforboneregeneration AT arghyapaul mineralnanoparticlesandnanocompositehydrogelswithosteoinductivepropertiesforboneregeneration |