Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

Development of Human Skin Equivalents with Inducible Ceramide Depletion for In Vitro Modeling of Lipid Impairment

The lipid composition of the epidermis plays a critical role in the skin’s barrier function, and defects in lipid synthesis or assembly can cause a spectrum of skin diseases, ranging from dry skin to severe ichthyoses. The aim of this study was to develop an in vitro model of human skin with tunable...

Full description

Saved in:
Bibliographic Details
Main Authors: Durotimi O. Dina, Miriam Maiellaro, Emanuela Camera, John T. Connelly
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:JID Innovations
Subjects:
3D model
Barrier function
Ceramide
CERS3
Lipidomics
Skin
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026725000396
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items