The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients
The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2024-09-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/2167 |
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| author | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze A. G. Solopova J. Kh. Khizroeva L. A. Ashrafyan V. N. Serov A. Е. Voynovskiy J. Yu. Ungiadze A. V. Lazarchuk M. V. Tretyakova N. A. Makatsariya P. V. Salnikova N. R. Gashimova K. N. Grigoreva K. L. Zakashansky I. Elalamy J.-C. Gris |
| author_facet | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze A. G. Solopova J. Kh. Khizroeva L. A. Ashrafyan V. N. Serov A. Е. Voynovskiy J. Yu. Ungiadze A. V. Lazarchuk M. V. Tretyakova N. A. Makatsariya P. V. Salnikova N. R. Gashimova K. N. Grigoreva K. L. Zakashansky I. Elalamy J.-C. Gris |
| author_sort | A. D. Makatsariya |
| collection | DOAJ |
| description | The results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During carcinogenesis, tumor cells express proinflammatory cytokines, proangiogenic and procoagulant factors, and also stimulate other cells to express various components promoting emerging thromboinflammation. The discovery of neutrophil extracellular traps (NETs) provides an opportunity to take a new look at biology and a role neutrophils may play in thromboinflammation and tumorigenesis. The close interplay between tumor cells, tumor-associated neutrophils and NETs as well as other players in the tumor microenvironment underlies activation of thromboinflammation in cancer patients not only resulting in thrombus formation, but also promoting tumor growth and dissemination. |
| format | Article |
| id | doaj-art-c6a27fe68f8c4d0e97198e8e40d1c965 |
| institution | Matheson Library |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-c6a27fe68f8c4d0e97198e8e40d1c9652025-08-03T19:55:18ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942024-09-0118445046310.17749/2313-7347/ob.gyn.rep.2024.542904The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patientsA. D. Makatsariya0E. V. Slukhanchuk1V. O. Bitsadze2A. G. Solopova3J. Kh. Khizroeva4L. A. Ashrafyan5V. N. Serov6A. Е. Voynovskiy7J. Yu. Ungiadze8A. V. Lazarchuk9M. V. Tretyakova10N. A. Makatsariya11P. V. Salnikova12N. R. Gashimova13K. N. Grigoreva14K. L. Zakashansky15I. Elalamy16J.-C. Gris17Sechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversityKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentShota Rustaveli Batumi State UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversityIcahn School of Medicine at Mount SinaiSechenov University; Medicine Sorbonne University; Hospital TenonSechenov University; University of MontpellierThe results of recent studies show that tumor biology, coagulation activation, and inflammatory reactions profoundly contribute to the thrombosis pathogenesis in cancer as well as tumor progression, metastasis, and developing chemoresistance. Cancer is an independent predictor of thrombosis. During carcinogenesis, tumor cells express proinflammatory cytokines, proangiogenic and procoagulant factors, and also stimulate other cells to express various components promoting emerging thromboinflammation. The discovery of neutrophil extracellular traps (NETs) provides an opportunity to take a new look at biology and a role neutrophils may play in thromboinflammation and tumorigenesis. The close interplay between tumor cells, tumor-associated neutrophils and NETs as well as other players in the tumor microenvironment underlies activation of thromboinflammation in cancer patients not only resulting in thrombus formation, but also promoting tumor growth and dissemination.https://www.gynecology.su/jour/article/view/2167thromboinflammationnetosisneutrophil extracellular trapsnetsneutrophilschemoresistancethrombosis |
| spellingShingle | A. D. Makatsariya E. V. Slukhanchuk V. O. Bitsadze A. G. Solopova J. Kh. Khizroeva L. A. Ashrafyan V. N. Serov A. Е. Voynovskiy J. Yu. Ungiadze A. V. Lazarchuk M. V. Tretyakova N. A. Makatsariya P. V. Salnikova N. R. Gashimova K. N. Grigoreva K. L. Zakashansky I. Elalamy J.-C. Gris The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients Акушерство, гинекология и репродукция thromboinflammation netosis neutrophil extracellular traps nets neutrophils chemoresistance thrombosis |
| title | The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients |
| title_full | The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients |
| title_fullStr | The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients |
| title_full_unstemmed | The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients |
| title_short | The concept of thromboinflammation underlying thrombotic complications, tumor progression and metastasis in gynecological cancer patients |
| title_sort | concept of thromboinflammation underlying thrombotic complications tumor progression and metastasis in gynecological cancer patients |
| topic | thromboinflammation netosis neutrophil extracellular traps nets neutrophils chemoresistance thrombosis |
| url | https://www.gynecology.su/jour/article/view/2167 |
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