CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation

CD44 is a macrophage receptor for TcdB from Clostridioides difficile that via its lysine-158 succinylation contributes to inflammation

Toxin B (TcdB) is a critical virulence factor in Clostridioides difficile-associated disease (CDAD), which activates macrophages to promote inflammation and epithelial damage. However, the mechanism by which TcdB targets inflammation-related receptors on the macrophage surface and the underlying mol...

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Bibliographic Details
Main Authors: Zhuo Chen, Wenzi Zhang, Danni Wang, Ruiqin Luo, Yuexin Yao, Xiaoyang Tao, Lu Li, Qin Pan, Xiaoming Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
TcdB
CD44
receptor
succinylation
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2506192
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