New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile
Introduction and Objectives: This study aims to assess the performance of Steatotic Liver Disease (SLD) criteria in identifying liver steatosis compared to the NAFLD and MAFLD definitions in an agricultural population in Chile. Patients and Methods: We performed a cross-sectional analysis on the MAU...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Annals of Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268125001449 |
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| author | Maria Spencer-Sandino Franco Godoy Laura Huidobro Danilo Alvares Francisco Cruz Claudia Marco Macarena Garrido Daniel Cabrera Juan Pablo Arab Marco Arrese Francisco Barrera Catterina Ferreccio |
| author_facet | Maria Spencer-Sandino Franco Godoy Laura Huidobro Danilo Alvares Francisco Cruz Claudia Marco Macarena Garrido Daniel Cabrera Juan Pablo Arab Marco Arrese Francisco Barrera Catterina Ferreccio |
| author_sort | Maria Spencer-Sandino |
| collection | DOAJ |
| description | Introduction and Objectives: This study aims to assess the performance of Steatotic Liver Disease (SLD) criteria in identifying liver steatosis compared to the NAFLD and MAFLD definitions in an agricultural population in Chile. Patients and Methods: We performed a cross-sectional analysis on the MAUCO cohort, composed of 9,013 individuals aged 38 to 74. Health conditions, socio-demographics, anthropometrics, hepatic ultrasonography, blood pressure, and biological samples were obtained. Participants were classified as NAFLD, MAFLD, or any of the five SLD categories: Metabolic dysfunction-associated steatosis liver disease (MASLD), Metabolic and Alcohol-Associated Liver Disease (MetALD), Alcohol-Associated Liver Disease (ALD), Specific aetiologies, and Cryptogenic. The Framingham cardiovascular risk score and BARD liver fibrosis score were used to assess clinical relevance. Results: Liver steatosis was present in 4,082 participants (45%); SLD criteria captured an additional 176 individuals not classified under NAFLD and 103 not included under MAFLD definition. The main SLD subgroups were MASLD (95%), MetALD (1.9%) and ALD (1.3%). Individuals classified in the MetALD and ALD subgroups exhibited more severe liver steatosis and a higher cardiovascular risk. Notably, participants categorized under specific etiologies and cryptogenic subgroups were younger and had a higher risk for liver fibrosis. Conclusions: The study reveals that SLD offers a more inclusive classification to identify high-risk individuals in the Chilean population, capturing cases that could be missed by NAFLD or MAFLD definitions by using the same resources. |
| format | Article |
| id | doaj-art-c61afd1abcf94e099a50fef1fff891d5 |
| institution | Matheson Library |
| issn | 1665-2681 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj-art-c61afd1abcf94e099a50fef1fff891d52025-07-05T04:46:47ZengElsevierAnnals of Hepatology1665-26812025-07-01302101919New steatotic liver disease criteria diagnostic performance in an agricultural population in ChileMaria Spencer-Sandino0Franco Godoy1Laura Huidobro2Danilo Alvares3Francisco Cruz4Claudia Marco5Macarena Garrido6Daniel Cabrera7Juan Pablo Arab8Marco Arrese9Francisco Barrera10Catterina Ferreccio11Escuela de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile; Advance Center for Chronic Diseases, ACCDIS, Universidad De Chile and Pontificia Universidad Católica de Chile, Santiago, ChileEscuela de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile; Advance Center for Chronic Diseases, ACCDIS, Universidad De Chile and Pontificia Universidad Católica de Chile, Santiago, ChileAdvance Center for Chronic Diseases, ACCDIS, Universidad De Chile and Pontificia Universidad Católica de Chile, Santiago, Chile; Departamento de Ciencias Preclínicas – Facultad de Medicina, Universidad Católica del Maule, Talca, ChileMRC Biostatistics Unit, University of Cambridge, UKDepartamento de Radiología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileEscuela de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile; Advance Center for Chronic Diseases, ACCDIS, Universidad De Chile and Pontificia Universidad Católica de Chile, Santiago, ChileEscuela de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto de Salud Pública de Chile, Santiago, ChileCentro de Investigación e Innovación en Biomedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile; Facultad de Ciencias Médicas, Universidad Bernardo O Higgins, Santiago, ChileDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond 23298, VA, USA; Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileEscuela de Salud Pública, Pontificia Universidad Católica de Chile, Santiago, Chile; Instituto de Salud Pública de Chile, Santiago, Chile; Corresponding author.Introduction and Objectives: This study aims to assess the performance of Steatotic Liver Disease (SLD) criteria in identifying liver steatosis compared to the NAFLD and MAFLD definitions in an agricultural population in Chile. Patients and Methods: We performed a cross-sectional analysis on the MAUCO cohort, composed of 9,013 individuals aged 38 to 74. Health conditions, socio-demographics, anthropometrics, hepatic ultrasonography, blood pressure, and biological samples were obtained. Participants were classified as NAFLD, MAFLD, or any of the five SLD categories: Metabolic dysfunction-associated steatosis liver disease (MASLD), Metabolic and Alcohol-Associated Liver Disease (MetALD), Alcohol-Associated Liver Disease (ALD), Specific aetiologies, and Cryptogenic. The Framingham cardiovascular risk score and BARD liver fibrosis score were used to assess clinical relevance. Results: Liver steatosis was present in 4,082 participants (45%); SLD criteria captured an additional 176 individuals not classified under NAFLD and 103 not included under MAFLD definition. The main SLD subgroups were MASLD (95%), MetALD (1.9%) and ALD (1.3%). Individuals classified in the MetALD and ALD subgroups exhibited more severe liver steatosis and a higher cardiovascular risk. Notably, participants categorized under specific etiologies and cryptogenic subgroups were younger and had a higher risk for liver fibrosis. Conclusions: The study reveals that SLD offers a more inclusive classification to identify high-risk individuals in the Chilean population, capturing cases that could be missed by NAFLD or MAFLD definitions by using the same resources.http://www.sciencedirect.com/science/article/pii/S1665268125001449Non-alcoholic fatty liver disease (NAFLD)Metabolic dysfunction-associated fatty liver disease (MAFLD)Steatotic Liver Disease (SLD) |
| spellingShingle | Maria Spencer-Sandino Franco Godoy Laura Huidobro Danilo Alvares Francisco Cruz Claudia Marco Macarena Garrido Daniel Cabrera Juan Pablo Arab Marco Arrese Francisco Barrera Catterina Ferreccio New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile Annals of Hepatology Non-alcoholic fatty liver disease (NAFLD) Metabolic dysfunction-associated fatty liver disease (MAFLD) Steatotic Liver Disease (SLD) |
| title | New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile |
| title_full | New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile |
| title_fullStr | New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile |
| title_full_unstemmed | New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile |
| title_short | New steatotic liver disease criteria diagnostic performance in an agricultural population in Chile |
| title_sort | new steatotic liver disease criteria diagnostic performance in an agricultural population in chile |
| topic | Non-alcoholic fatty liver disease (NAFLD) Metabolic dysfunction-associated fatty liver disease (MAFLD) Steatotic Liver Disease (SLD) |
| url | http://www.sciencedirect.com/science/article/pii/S1665268125001449 |
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